Solid Oral Controlled-Release Formulations

Bhansali, Mitesh; Dabholkar, Neha; Swetha, P.; Dubey, Sunil Kumar; Singhvi, Gautam

doi:10.1016/b978-0-12-821185-4.00007-5

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…The resulting material is more heat resistant, less hygroscopic, and has the lowest affinity toward proteins of all the derivatives previously mentioned. 177 However, the process of acetylation renders CA more brittle and, depending upon the degree of substitution, renders the material less biodegradable than pure cellulose. 178 Unlike cellulose, CA is also more soluble in organic solvents.…”

Section: Membrane Materials and Functionalization Strategiesmentioning

confidence: 99%

Integrated membranes within centrifugal microfluidic devices: a review

O'Connell

Landers

2023

Lab Chip

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Section: Membrane Materials and Functionalization Strategiesmentioning

confidence: 99%

Integrated membranes within centrifugal microfluidic devices: a review

O'Connell

Landers

2023

Lab Chip

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“…Cellulose is the natural biopolymer that is found in the greatest abundance on the planet [ 17 ]. Among the most significant cellulose derivatives is cellulose acetate (CA) [ 19 ], which is extracted and synthesized from renewable and natural resources [ 20 , 21 ]. CA has attracted considerable attention, as it is a biodegradable polymer with hydrophilic features, excellent chemical and mechanical stability, and low toxicity [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Ag/ZnO Reinforcements on the Anticancer and Biological Performances of CA@Ag/ZnO Nanocomposite Materials

Alahmadi

Hussein

2023

Molecules

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In this study, an unpretentious, non-toxic, and cost-effective dissolution casting method was utilized to synthesize a group of anticancer and biologically active hybrid nanocomposite materials containing biopolymer cellulose acetate. Pristine ZnO and Ag(0.01, 0.05, 0.1)/ZnO hybrid nanofillers based on variable Ag NP loadings were prepared via green procedures in the presence of gum arabic (GA). The chemical structures and the morphological features of the designed nanocomposite materials were investigated by PXRD, TEM, SEM, FTIR, TGA, and XPS characterization techniques. The characterization techniques confirmed the formation of CA@Ag(0.01, 0.05, 0.1)/ZnO hybrid nanocomposite materials with an average crystallite size of 15 nm. All investigated materials showed two degradation steps. The thermal stability of the fabricated samples was ranked in the following order: CA/ZnO < CA@Ag(0.01)/ZnO < CA@Ag(0.05)/ZnO = CA@Ag(0.1)/ZnO. Hence, the higher Ag doping level slightly enhanced the thermal stability. The developed nanocomposites were tested against six pathogens and were used as the target material to reduce the number of cancer cells. The presence of Ag NPs had a positive impact on the biological and the anticancer activities of the CA-reinforced Ag/ZnO composite materials. The CA@Ag(0.1)/ZnO hybrid nanocomposite membrane had the highest antimicrobial activity in comparison to the other fabricated materials. Furthermore, the developed CA@Ag(0.1)/ZnO hybrid nanocomposite material effectively induced cell death in breast cancer.

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