Solid organ procurement from donors with carbon monoxide poisoning and/or burn - a systematic review

Busche, Marc N.; Knobloch, Karsten; Herold, Christian; Krämer, Robert; Vogt, Peter M.; Rennekampff, Hans‐Oliver

doi:10.1016/j.burns.2011.02.002

Cited by 16 publications

(15 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To minimise the impact of any of these potential co-founders, using a multivariate analysis of cocaine-and non-cocaine-matched donors, there was no difference in the propensity of recipient survival based on donor cocaine status (p=0.31). The impact of donor death from carbon monoxide toxicity on recipient outcome for a range of solid organs has been studied using a systematic review of the published literature [10]. A total of 42 carbon monoxide-related donor deaths (36 adults with carbon monoxide poisoning and 6 children with carbon monoxide poisoning and burns) from whom solid organs were transplanted were identified, and follow-up was up to 7 years for individual organs.…”

Section: Discussionmentioning

confidence: 99%

Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting

Wood

Chan

2014

J. Med. Toxicol.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting

Wood

Chan

2014

J. Med. Toxicol.

View full text Add to dashboard Cite

show abstract

“…CO poisoning is responsible for a high number of intoxication deaths in Europe and USA [5,6,9,10]. Patients dying following CO intoxication are routinely considered not suitable to organ donation because of severe hypoxic tissue injury [1,4,5]. Meanwhile, the indications for transplantation have increased and expanding the donor pool is a high priority.…”

Section: Discussionmentioning

confidence: 99%

“…Mesenteric ischemia may also occur following CO exposure, leading mostly to ischemic colitis [11,12]. In spite of the above concerns, solid organ procurements from CO intoxicated donors and from some having tumors, though controversial, have been reported [4,7,10]. In the present work, we illustrate a case of multiorgan procurement and transplantation from a brain death victim of CO intoxication, who also has an intraoperatively diagnosed right colon tumor.…”

Section: Introductionmentioning

confidence: 91%

“…Irreversible myocardial damage from CO poisoning has been linked to elevated creatinine kinase (CK) levels. Also, an increase in the MB/ isozyme fraction with ECG abnormalities [4,5] and 20% carboxihemoglobin (CO Hb) levels have been associated with an increase of vascular permeability by endothelial lesions [4]. Beyond central nervous system hypoxic injury, irreversible myocardial injury linked to CO intoxication and splanchnic limited or extended ischemia can increase long-term mortality in patients surviving CO poisoning [4,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Also, an increase in the MB/ isozyme fraction with ECG abnormalities [4,5] and 20% carboxihemoglobin (CO Hb) levels have been associated with an increase of vascular permeability by endothelial lesions [4]. Beyond central nervous system hypoxic injury, irreversible myocardial injury linked to CO intoxication and splanchnic limited or extended ischemia can increase long-term mortality in patients surviving CO poisoning [4,6,7]. Even if myocardial damage may be present in nearly 40% of poisoned individuals, the most common cause of death is anoxic brain injury [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Unforeseen Pseudotumoral Colitis in Deceased Donor with Carbon Monoxide Intoxication

Lupașcu¹,

Movila²,

Andriesi³

et al. 2014

J Clin Toxicol

View full text Add to dashboard Cite

Carbon monoxide intoxication is a well-known cause of hypoxic injury primarily to the central nervous system and myocardium, but the bowel may be also vulnerable. Patients succumbing to carbon monoxide poisoning are usually considered unsuitable for organ procurement and they are routinely rejected in many transplant centers. As the organ supply is by far insufficient to meet the needs of patients from the waiting lists for transplant, there is a greater effort to increase the donor organ pool. Therefore special attention is being devoted to such "marginal" or "high-risk "donors. Similarly, tumors revealed during organ procurement require careful consideration in the evaluation of organ donors and transplant recipients. We herein report a multiorgan procurement from a victim of carbon monoxide poisoning who underwent a prolonged cardiopulmonary resuscitation and was intraoperatively diagnosed with a right colon tumor. Intraoperative frozen section examination ruled out malignancy and revealed an acute ischemic colitis. It is suggested that patients dying of carbon monoxide poisoning who are considered appropriate donors, may have intraoperatively revealed pseudotumoral ischemic colitis which does not preclude multiorgan procurement.

show abstract

Carbon monoxide: An emerging therapy for acute kidney injury

Yang

Caestecker

Otterbein

et al. 2019

Medicinal Research Reviews

View full text Add to dashboard Cite

Treating acute kidney injury (AKI) represents an important unmet medical need both in terms of the seriousness of this medical problem and the number of patients. There is also a large untapped market opportunity in treating AKI. Over the years, there has been much effort in search of therapeutics with minimal success. However, over the same time period, new understanding of the underlying pathobiology and molecular mechanisms of kidney injury have undoubtedly helped the search for new therapeutics. Along this line, carbon monoxide (CO) has emerged as a promising therapeutic agent because of its demonstrated cytoprotective, and immunomodulatory effects. CO has also been shown to sensitize cancer, but not normal cells, to chemotherapy. This is particularly important in treating cisplatin-This is the author manuscript accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

show abstract

Solid organ procurement from donors with carbon monoxide poisoning and/or burn - a systematic review

Cited by 16 publications

References 41 publications

Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting

Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting

Unforeseen Pseudotumoral Colitis in Deceased Donor with Carbon Monoxide Intoxication

Carbon monoxide: An emerging therapy for acute kidney injury

Contact Info

Product

Resources

About