Solid-Phase Dendrimer Synthesis and the Generation of Super-High-Loading Resin Beads for Combinatorial Chemistry

Dendritic supports in organic synthesis

“…Ž . aGel Swali et al, 1997 . Build-up of the dendritic linkers was performed on the resin beads, Ž i.e.…”

Isocyanate-Based Dendritic Building Blocks: Combinatorial Tier Construction and Macromolecular-Property Modification

“…Formation of these compounds is supported by their 13 C NMR spectra (Figures 1 and 2, Table 1). Anticipated key absorptions corresponding to the Figure 1. 13 C NMR spectra for the peripherally homogeneous ester, cyano, and siloxane dendrimers 6, 7, and 8, respectively, and the peripherally heterogeneous dendrimers 11 (prepared from 0.5, 0.4, and 0.1 equivalents of monomers 1, 2, and 3, respectively) and 12 (0.7, 0.15, and 0.15 equivalents of 1, 2, and 3, respectively).…”

“…We herein report on the concept of the rapid modification of properties through combinatorial synthesis analogous to that used for the discovery of novel solid-state materials, [9] biologically active substrates, [10] and artificial receptors. [11] While dendrimers have recently been employed [12] and touted [13,14] as vehicles for the generation of standard small-molecule libraries, our combinatorial method relies on mixtures of AB 3 -type monomers having varying compositions of different, yet mutually compatible building COMMUNICATIONS blocks for sequential formation of ªtiersº and dendrimer construction.…”

Dendrimer construction and macromolecular property modification via combinatorial methods

“…Key attributes of this approach included solution-phase chemistry, homogeneous purification, and high-support loadings. Subsequently, Bradley and coworkers 19 prepared PAMAM-like dendrons (anchored dendritic wedges) attached to a TentaGel solid-phase support. Only the synthesis and cleavage of the uniform PAMAM fragments were reported; no combinatorial syntheses were mentioned.…”