Solid Phase Derivatization Reactions in HPLC

Band broadening in solid phase reactors packed with catalyst for reactions in continuous-flow systems

“…The advantages of solid-state reactions in LC, wherein the reagent is present as solid, supported on an inert medium or chemically bonded to a suitable support, have been recently also recognized and reviewed by Krull and Lankmayr (4). In a very recent paper Krull et al (5) have discussed more concretely the polymeric reduction of carbonyl compounds following separation by LC. Of even higher actuality is the use of the reactor bed material as catalyst, where the solid support is not consumed and can therefore be used repeatedly over a prolonged period of time, provided that no catalyst poisoning takes place. The concept of heterogeneous catalysis in solid phase reactors, i.e., for catalytic hydrolysis or redox reactions, is quite new.…”