Solid-phase synthesis for beginners: Choice of tools and techniques for implementation of multistage transformations

Abstract

Abstract-Several mini-libraries were prepared by solid-phase synthesis: C,N-substituted glycines (1) and 2,5-diaminobenzoic acids (2) using Wang resin as well as diarylthioureas (3) and diaryl-guanidines (4) using Rink resin. Comparative analysis of the instruments and technique for these reactions was provided by applying glass vials with filters (BillBoard kit) to prepare the class (1), the tea-bag technique for the class (2), and plastic rods (Lanterns) for the classes (3) and (4). All reactions (supplied with detailed protocols) were optimized for use as a tool of practical student education.