Solid-phase synthesis of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives

Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye

“…Significant progress with such analogues has let to advances in cancer chemotherapy and anti HBV and HIV applications. The lack of an effective therapy to treat hepatitis B virus and HIV infections, particularly in chronic cases has focused considerable effort into the synthesis of nucleoside analogues possessing antiviral activity [22][23][24]. Some analogues having either modified bases and/or glycosyl residues have shown promise in antiparasite chemotherapy [25,26] for cytokinin activities [42,43] as antihypertensive agent [44], as biochemical tools [45,46] and as inhibitors of cellular enzymes [47,48].…”

“…Phthalazine derivatives were reported to possess anticonvulsant [7], antitumor [8], antihypertensive [9], antithrombotic [10], antidiabetic [11], antitrypanosomal [12], anti-inflammatory [13], cardiotonic [14] and vasorelaxant activities [15]. Therefore, number of methods have been reported for the synthesis of phthalazine derivatives [16][17][18][19][20][21][22]. Despite the available methods, the development of new synthetic methods for the efficient preparation of phthalazinone derivative is therefore an interesting challenge.…”

Heteropoly Acid in Ionic Liquid - An Efficient Catalyst for the Preparation of 2H-Indazolo[2,1-b]Phthalazine-Triones

“…The combined ether extractions were dried over Na 2 SO 4 , concentrated and the residue recrystallized from ethyl acetate/n-hexane (1:3) to afford the pure product. The products 4a-4f are known compounds, and their structures were deduced by comparison of their physical and spectroscopic data with those previously reported [9][10][11][12]. …”

“…Phthalazine derivatives were reported to possess vasorelaxant [2], cardiotonic [3], and anticonvulsant [4], activities. Therefore, a number of methods have been reported in the literature for the synthesis of phthalazine derivatives [4][5][6][7][8][9][10][11]. Unfortunately, many of these processes suffer from one or other limitations such as harsh reaction conditions, low product yields, tedious workup procedures, relatively long reaction times, and cooccurrence of several side products, and difficulty in recovery and reusability of the catalysts.…”

Efficient CAN catalyzed synthesis of 1H-indazolo[1,2-b] phthalazine-1,6,11-triones: An eco-friendly protocol

“…These compounds have also proved to be promising luminescence materials and fluorescence probes [35]. Several methods have been reported for the synthesis of phthalazine derivatives [36][37][38][39][40][41]. Unfortunately, many of these methods are plagued with a number of limitations, such as harsh reaction conditions, unsatisfactory yields, tedious work-up procedures, relatively long reaction times, poor solvent scope and the use of stoichiometric and relatively expensive reagents.…”