Solid-Phase Synthesis of Cyclosporin Peptides

Angell, Yvonne M.; Thomas, Timothy L.; Flentke, George R.; Rich, Daniel H.

doi:10.1021/ja00132a042

Cited by 70 publications

(54 citation statements)

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“…253 A challenge then is to relate this picture to ͑a͒ the energy landscape scenario in which the excitation profile is in focus, and its steepness, scaled by the Kauzmann temperature, is a measure of the fragility, and ͑b͒ the anharmonicity scenario 254 in which the quasielastic scattering, and indirectly the whole of the relaxation time temperature dependence, is connected to the relation between 3rd and 4th order anharmonicity coefficients for the boson peak vibrations. It is here that we may understand, through the anharmonicity coupling of the vibrational and configurational energy manifolds, the reason that the T g tends to scale with the Debye temperature in many simple glasses, 255 but greatly to exceed it in stronger glassformers. The occurrence of the related umklapp processes ͑momentum conserving͒ in glasses and liquids 255 is only now being recognized as a physical reality.…”

Section: D52 Ultrahigh Frequency and High Q Measurementsmentioning

confidence: 93%

“…It is here that we may understand, through the anharmonicity coupling of the vibrational and configurational energy manifolds, the reason that the T g tends to scale with the Debye temperature in many simple glasses, 255 but greatly to exceed it in stronger glassformers. The occurrence of the related umklapp processes ͑momentum conserving͒ in glasses and liquids 255 is only now being recognized as a physical reality. 256 Another accomplishment of the inelastic x-ray scattering technique is to observe the viscoelastic behavior of liquids on the picosecond time scale and to determine the structural relaxation from the ϭ1 condition in this highly fluid regime.…”

Section: D52 Ultrahigh Frequency and High Q Measurementsmentioning

confidence: 93%

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Relaxation in glassforming liquids and amorphous solids

Angell

Ngai

McKenna

et al. 2000

Journal of Applied Physics

2,122

1,876

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The field of viscousliquid and glassysolid dynamics is reviewed by a process of posing the key questions that need to be answered, and then providing the best answers available to the authors and their advisors at this time. The subject is divided into four parts, three of them dealing with behavior in different domains of temperature with respect to the glass transition temperature, Tg,and a fourth dealing with "short time processes. " The first part tackles the high temperature regime T>Tg, in which the system is ergodic and the evolution of the viscousliquid toward the condition at Tg is in focus. The second part deals with the regime T∼Tg, where the system is nonergodic except for very long annealing times, hence has time-dependent properties (aging and annealing). The third part discusses behavior when the system is completely frozen with respect to the primary relaxation process but in which secondary processes, particularly those responsible for "superionic" conductivity, and dopart mobility in amorphous silicon, remain active. In the fourth part we focus on the behavior of the system at the crossover between the low frequency vibrational components of the molecular motion and its high frequency relaxational components, paying particular attention to very recent developments in the short time dielectric response and the high Qmechanical response. The field of viscous liquid and glassy solid dynamics is reviewed by a process of posing the key questions that need to be answered, and then providing the best answers available to the authors and their advisors at this time. The subject is divided into four parts, three of them dealing with behavior in different domains of temperature with respect to the glass transition temperature, T g , and a fourth dealing with ''short time processes.'' The first part tackles the high temperature regime TϾT g , in which the system is ergodic and the evolution of the viscous liquid toward the condition at T g is in focus. The second part deals with the regime TϳT g , where the system is nonergodic except for very long annealing times, hence has time-dependent properties ͑aging and annealing͒. The third part discusses behavior when the system is completely frozen with respect to the primary relaxation process but in which secondary processes, particularly those responsible for ''superionic'' conductivity, and dopart mobility in amorphous silicon, remain active. In the fourth part we focus on the behavior of the system at the crossover between the low frequency vibrational components of the molecular motion and its high frequency relaxational components, paying particular attention to very recent developments in the short time dielectric response and the high Q mechanical response.

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Section: D52 Ultrahigh Frequency and High Q Measurementsmentioning

confidence: 93%

Section: D52 Ultrahigh Frequency and High Q Measurementsmentioning

confidence: 93%

Relaxation in glassforming liquids and amorphous solids

Angell

Ngai

McKenna

et al. 2000

Journal of Applied Physics

2,122

1,876

View full text Add to dashboard Cite

show abstract

“…Configuron quasiparticles were introduced first by Angell [29] based on the idea that there are groups of atoms in a disordered material that at high anharmonicity have simultaneously moved far enough from their original positions so that it becomes energetically unfavourable for them to return. A configuron is an elementary configurational excitation in an amorphous material, formed by breaking of a chemical bond and the associated strain-releasing local adjustment of centres of atomic vibration [24,29].…”

Section: Congruent Bond Lattice (Cbl) Model and Configuronsmentioning

confidence: 99%

Connectivity and glass transition in disordered oxide systems

Ojovan

Lee

2010

Journal of Non-Crystalline Solids

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“…A similar strategy but this time using an Asp-side chain linked to polystyrene RAM resin has been used [133] Yields of 31-37% were achieved at the on-resin cyclization stage using HATU/HOAt. [134]. Availability of HOAt and HATU, and utilizing double couplings in many places proved to be critical to the success.…”

Section: Cyclodecapeptidesmentioning

confidence: 99%

The cyclization of peptides and depsipeptides

Davies

2003

Journal of Peptide Science

417

241

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Constricting the peptide backbone into a more defined conformational form through cyclization is an activity evolved in nature and in synthetic work, the latter straddling only the most recent decades. The resulting conformational constraints increase the probability of an optimum response with bio-receptors. The purpose of this review is to highlight developments that have proved to be reasonably efficient in the macrocyclization of linear precursors into cyclic peptides and depsipeptides.

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Solid-Phase Synthesis of Cyclosporin Peptides

Cited by 70 publications

References 0 publications

Relaxation in glassforming liquids and amorphous solids

Relaxation in glassforming liquids and amorphous solids

Connectivity and glass transition in disordered oxide systems

The cyclization of peptides and depsipeptides

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