Solid-phase synthesis of dendritic sialoside inhibitors of influenza A virus haemagglutinin

Roy, René; Zanini, Diana; Meunier, Serge J.; Romanowska, Anna

doi:10.1039/c39930001869

Cited by 270 publications

(147 citation statements)

References 16 publications

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“…polyamido amine) and from amino acids (e.g. polylysine) and carbohydrates [12][13][14]. There are two main methods to synthesize dendrimers [12,15]: (i) divergent synthesis where a core molecule with multiple reactive sites is used to form chemical bonding with a reactant and where the formed complex is later reacted with a molecule capable of generating another branching point and (ii) convergent synthesis where fragments of dendrimers are added to the core molecules and thus assembled.…”

Section: Introductionmentioning

confidence: 99%

Osteoconductive phosphoserine-modified poly(ε-lysine) dendrons: synthesis, titanium oxide surface functionalization and response of osteoblast-like cell lines

Meikle

Bianchi²,

Olivier

et al. 2013

J. R. Soc. Interface.

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The lack of direct bonding between the surface of an implant and the mineralized bony tissue is among the main causes of aseptic loosening in titaniumbased implants. Surface etching and ceramic coatings have led to improved osteointegration, but their clinical performance is still limited either by partial bonding or by coating delamination. In this work, a solid-phase synthesis method has been optimized to produce poly(1-lysine) dendrons, the outermost branching generation of which is functionalized by phosphoserine (PS), a known catalyst of the biomineralization process. The dendrons were deposited onto etched titanium oxide surfaces as a near-to-monolayer film able to induce the formation of a homogeneous calcium phosphate phase in a simulated body fluid over 3 days. The dendron films also stimulated MG63 and SAOS-2 osteoblast-like cells to proliferate at a rate significantly higher than etched titanium, with SAOS-2 also showing a higher degree of differentiation over 14 days. PS-tethered dendron films were not affected by various sterilization methods and UV treatment appeared to improve the cell substrate potential of these films, thus suggesting their potential as a surface functionalization method for bone implants.

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Section: Introductionmentioning

confidence: 99%

Osteoconductive phosphoserine-modified poly(ε-lysine) dendrons: synthesis, titanium oxide surface functionalization and response of osteoblast-like cell lines

Meikle

Bianchi²,

Olivier

et al. 2013

J. R. Soc. Interface.

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“…[1][2][3][4][5] For biomedical applications in particular, dendrimers are promising materials because functional nano-devices require a controlled three-dimensional architecture with appropriate functional groups at designated sites. [6][7][8][9][10][11] Because dendrimers are synthesized by precisely controlled stepwise reactions, designers have the freedom to introduce functional groups at specific sites.…”

Section: Introductionmentioning

confidence: 99%

Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications

Jeong

Yoon

Jang

2012

Polym J

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Dendrimers have attracted great interest for the design of functional materials. Because the core porphyrin unit in dendrimer porphyrin (DP) is surrounded by large poly(benzyl ether) dendritic wedges with ionic peripheries, the resulting electrostatic interaction with oppositely charged polymeric materials has been used to create various functional nano-devices. In this paper, we briefly review DP-based self-assembled biomedical nano-devices, including DP-loaded polyion complex micelles, the ternary complex systems used for gene delivery, polymer-metal complex micelles, the hollow nanocapsules used for combination cancer therapy, and the DP-immobilized surfaces used for diagnostic tools.

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“…The globular macromolecule, poly(L-lysine) dendrimer (PLLD) was coupled to the linear PEG by the repetitive liquid-phase peptide synthesis method. 10 Poly(L-lysine) dendrimer [11][12][13] is another polycationic dendrimer containing a large number of surface amines and considered to be capable of electrostatic interaction with nucleic acids.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Linear Polymer-Dendrimer Block Copolymer/Plasmid DNA Complexes: Formation of Core-shell Type Nanoparticles with DNA and Application to Gene Delivery in Vitro

Choi¹,

Choi²,

Park³

2004

Bulletin of the Korean Chemical Society

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A hybrid linear polymer-dendrimer block copolymer, poly(ethylene glycol)-block-poly(L-lysine) dendrimer, was synthesized and introduced to form polyionic complexes with DNA. The copolymer formed core-shell type nanoparticles with plasmid DNA. From dynamic light scattering experiments, the mean diameter of the polyplexes was observed to be 154.4 nm. The complex showed much increased water solubility compared to poly(L-lysine). The plasmid DNA in polyplexes was efficiently protected from the enzymatic digestion of DNase I. The cytotoxicity and transfection efficiency for 293 cells was measured in comparison with poly(Llysine).

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Solid-phase synthesis of dendritic sialoside inhibitors of influenza A virus haemagglutinin

Abstract: Efficient solid-phase synthesis of dendritic a-thiosialoside inhibitors of influenza A virus haemagglutinin are described using hyperbranched L-lysine core structures.

Cited by 270 publications

References 16 publications

Osteoconductive phosphoserine-modified poly(ε-lysine) dendrons: synthesis, titanium oxide surface functionalization and response of osteoblast-like cell lines

Osteoconductive phosphoserine-modified poly(ε-lysine) dendrons: synthesis, titanium oxide surface functionalization and response of osteoblast-like cell lines

Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications

Characterization of Linear Polymer-Dendrimer Block Copolymer/Plasmid DNA Complexes: Formation of Core-shell Type Nanoparticles with DNA and Application to Gene Delivery in Vitro

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