Solid-phase synthesis of quinoxalines on SynPhase™ Lanterns

Nano-kaoline/BF3/Fe3O4 Eco-friendly Nano-catalyst Promoted Synthesis of Quinoxalines Under Grinding Condition

“…These compounds have been applied in electron luminescent materials [2], uorescent dyes [3], chemically controllable switches [4], organic semiconductors [5], building blocks for the synthesis of anion receptor [6], dehydroannulenes [7], and DNA cleaving agents [8]. Quinoxalines play an important role in the design of a number of antibiotics such as echinomycin [9], actinomycin [10], and levomycin [10]. These compounds inhibit the growth of gram-positive bacteria and are active against various transplantable tumors [9,10].…”

“…Quinoxalines play an important role in the design of a number of antibiotics such as echinomycin [9], actinomycin [10], and levomycin [10]. These compounds inhibit the growth of gram-positive bacteria and are active against various transplantable tumors [9,10]. In addition, quinoxalines have biological activities such as antiviral [11], anticancer [12], antibacterial [13], antifungal [14], antidepressant [15], anti-HIV [16], and anti-in ammatory [17].…”

Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives

“…Numerous methods are available for the synthesis of quinoxaline derivatives which involve condensation of 1,2-diamines with α-diketones [19,20], 1,4-addition of 1,2-diamines to diazenylbutenes [21], cyclization-oxidation of phenacyl bromides [22,23] and oxidative coupling of epoxides with ene-1,2-diamines [24], 2,3-Disubstituted quinoxalines have also been prepared via the Suzuki-Miyaura coupling reaction [25], condensation of o-phenylenediamines with 1,2-dicarbonyl compounds in MeOH/AcOH under microwave irradiation [26] and iodine catalyzed cyclocondensation of 1,2-dicarbonyl compounds with substituted o-phenylenediamines in DMSO [27] or CH 3 CN [28].…”

Sodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives

“…In addition, 1,5-benzodiazepines are intermediates used for the synthesis of other fused ring compounds such as triazolo-, oxazino-or furanobenzodiazepines (Essaber et al, 1998;El-snyed et al, 1999;Xu et al, 1999;Zhang et al, 1999;Reddy et al, 2000). On the other hand, quinoxaline derivatives have also shown a broad spectrum of biological activities, which has led them to be privileged structures in drug discovery (Zaragoza and Stephensen, 1999;Wu and Ede, 2001).…”