Solid Phase Synthesis: The Use of Solid Supports and Insoluble Reagents in Peptide Synthesis

Phenyl acrylates and divinyl benzene cross‐linked copolymers as basic novel supports: Synthesis and characterization

“…Generally, the swelling properties of the polymer support depends on two factors: ( i ) cross-link ratio and (ii) chemical nature of the polymer support employed. 35 It is known from the literature that microporous resins possess porosity only in a swollen condition because of "swelling," also known as gel p~r o s i t y .~ Since the resins under study are microporous in nature, the swelling studies are important for identifying the good solvent in order to select the suitable reaction medium for performing reactions on polymer supports. 36 To investigate the swelling behavior of these copolymer supports, solvent imbibition studies were undertaken.…”

A Graphite Supported Chiral Catalyst

“…The benzene solution was refluxed for 24 h and the water produced was drawn oft continously. The solid (8) was filtered, washed with benzene and ethanol and dried in vacuum. Analysis: S, 1.54% (0.5 x 10-3 eq/g).…”

“…Analysis: S, 1.54% (0.5 x 10-3 eq/g). Phosphinated graphite (8). A solution of LiP(CoH,) in THF, prepared from 0.7 g P(CoH,)2CI and excess lithium metal, was added to a suspension of graphite ditosylate (7) (2.5 g) in THF.…”

Solid phase synthesis of hydrophobic peptides on 1,6-hexanediol diacrylate cross-linked polystyrene resin

“…Innumerable investigations dealing with the quantitative aspects of polymer supported reactions during the last two decades have shown that the insoluble support has a significant influence on the bound substrates. The success of solid phase synthesis depends on the swelling characteristics of the polymer and the solvation of the peptidyl resin in different solvents [3]. Hence, polymeric systems that swell and solvate to a high degree in solvents used for peptide synthesis have high reactivities.…”