Solid-pseudopapillary carcinoma: a case study and literature review

Zin, Anani Aila Mat; Shakir, K A R; Aminuddin, A R; Mahedzan, M R; Irnawati, W A R; Andee, Dzulkarnaen Zakaria; Hassan, Shahid; Ezane, M A; Hasnan, M N

doi:10.1136/bcr-2012-006495

Cited by 5 publications

(10 citation statements)

References 22 publications

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“…However, they do remain a rare neoplasm and owing to the fact that they typically present with vague, non-specific symptoms, they can pose as a diagnostic challenge 3 6. SPNs have a low malignant potential and as a result they are associated with good prognosis 1 3 6–8. Even in the setting of metastatic disease, long-term survival following resection remains high 12.…”

Section: Discussionmentioning

confidence: 99%

“…Even in the setting of metastatic disease, long-term survival following resection remains high 12. The mainstay of treatment for SPNs confined to the pancreas is complete surgical excision 1 10. Ninety-five per cent of patients are completely cured when R0 resection is achieved 3 10.…”

Section: Discussionmentioning

confidence: 99%

“…Ninety-five per cent of patients are completely cured when R0 resection is achieved 3 10. The most commonly employed surgical procedures include local resection, distal pancreatectomy and pancreaticoduodenectomy 1. Malignant behaviour is typically predicted based on the existence of vascular and neural invasion, invasion to surrounding tissue or the presence of distant metastases 1.…”

Section: Discussionmentioning

confidence: 99%

“…Solid-pseudopapillary neoplasms (SPNs) of the exocrine pancreas1–5 account for about 2% of all exocrine pancreatic malignancies 1 3 4. SPNs affect predominantly women (>90% female dominance) during their second and third decades of life 4–8.…”

Section: Introductionmentioning

confidence: 99%

“…The majority of patients with SPNs present with vague symptoms and the rest are discovered incidentally 1 3 7 8 10. Symptoms often develop late when the tumour is large enough to cause compression of adjacent viscera 5.…”

Section: Introductionmentioning

confidence: 99%

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Surgical therapy of a large pancreatic solid-pseudopapillary neoplasm during pregnancy

et al. 2014

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SUMMARYSolid-pseudopapillary neoplasms (SPNs) of the exocrine pancreas are rare, accounting for only 2% of pancreatic tumours. These tumours predominantly affect women during the second and third decades of life. They frequently present with vague symptoms and can pose a diagnostic challenge. Surgical resection remains the treatment of choice that can cure up to 95% of patients when negative resection margins are obtained. SPNs diagnosed during pregnancy are exceptional and with profound implications on the mother and fetus. The authors present a case of an asymptomatic SPN in a 24-year-old woman diagnosed at 14 weeks of gestation on a routine prenatal ultrasound. Distal pancreatectomy, splenectomy and cholecystectomy were successfully performed at 18 weeks of gestation. A healthy full-term male child was born 5 months following surgery without complications. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical therapy of a large pancreatic solid-pseudopapillary neoplasm during pregnancy

et al. 2014

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Solid Pseudopapillary Neoplasms of the Pancreas: A Surgical and Genetic Enigma

et al. 2017

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Solid pseudopapillary neoplasms of the pancreas are rare tumors accounting for 1-2% of pancreatic exocrine neoplasms. This entity was first described by Dr. Frantz in 1959 and was defined by the World Health Organization in 1996 as "solid pseudopapillary tumor." It is most often a benign neoplasm, but 10-15% of the cases are malignant. Over the past decades, the incidence of this tumor is increasing. However, many surgeons are still unfamiliar with this neoplasm and its unique characteristics, which can lead to pitfalls in the diagnosis and treatment. The correct diagnosis of SPNP is of utmost importance since it has a low malignant potential and with the appropriate treatment, patients have a long life expectancy. There are many genetic alterations, involving various signaling pathways that have been associated with SPNP and are very important in diagnosing the tumor. The cornerstone of SPNP treatment includes surgical excision of the tumor, preserving as much pancreatic tissue as possible. We review the information in the literature regarding more organ-preserving techniques and possible clinical features that might indicate a malignant potential, thus demanding a more radical intraoperative excision.

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