Solid-pseudopapillary neoplasm of the pancreas in children: Can we predict malignancy?

Hwang, Jai Hyun; Kim, Dae Yeon; Kim, Seong Chul; Namgoong, Jung‐Man; Hong, Seung‐Mo

doi:10.1016/j.jpedsurg.2014.09.011

Cited by 54 publications

(48 citation statements)

References 17 publications

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“…[16] Indeed, radical resection is associated with better OS and RFS than nonradical alternatives in patients with various types of malignant or benign pancreatic tumors. [34] …”

Section: Discussionmentioning

confidence: 99%

Radical resection and enucleation in Chinese adolescents with pancreatic tumors

Yang

Xie²,

Jin³

et al. 2017

Medicine

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Pancreatic tumors rarely occur in adolescents, and the appropriateness of radical resection for these patients remains controversial.Medical records were retrospectively reviewed for patients younger than 19 years who underwent radical resection or limited resection (enucleation) between 2000 and 2015. Patient demographics, clinical characteristics, operative details, growth, and survival were analyzed.During the study period, 11 adolescents (mean age, 16.18 years; standard deviation, 1.99; interquartile range, 15.0–18.0) underwent radical resection (n = 7) or enucleation (n = 4) to treat solid pseudopapillary tumors (n = 5), pancreatic neuroendocrine tumors (n = 5), or pancreatic ductal adenocarcinoma (n = 1). None of the 7 patients who underwent radical resection experienced recurrence or serious complications, while 3 of 4 patients who underwent enucleation experienced recurrence (P = 0.02). Recurrence-free survival was slightly longer in patients who underwent radical resection, and this procedure did not appear to affect adolescent growth and development.Radical resection might be safe and effective for adolescents with pancreatic tumors.

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“…[16] Indeed, radical resection is associated with better OS and RFS than nonradical alternatives in patients with various types of malignant or benign pancreatic tumors. [34] …”

Section: Discussionmentioning

confidence: 99%

Radical resection and enucleation in Chinese adolescents with pancreatic tumors

Yang

Xie²,

Jin³

et al. 2017

Medicine

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“…In a systematic review of the English literature, including 2744 cases of SPNs, approximately 11 % of cases were managed with limited resection, 9 % treated with tumor enucleation and 4 % with central pancreatectomy [16]. However, the oncologic safety of tissue-sparing minimal resections remains a real concern [27][28][29]. Limited resections were performed in two cases in our series, one patient with a small lesion of the pancreatic body underwent central pancreatectomy and another with two synchronous lesions underwent resection of the uncinate process and tumor enucleation of a lesion located in the tail.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic surgery for tumors in children and adolescents

Casamassima¹,

Gause²,

Goldstein³

et al. 2016

Pediatr Surg Int

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“…Although SPT is usually located in the tail and body of the pancreas (3)(4)(5), the caput pancreas is also a frequent location (6). Patients with SPT may present with complaints of abdominal pain and discomfort, and the diagnosis of SPT may be incidental (3,6).…”

Section: Discussionmentioning

confidence: 99%

“…However, in another study, the solid component of the tumor was considered to be a significant predictor of malignant potential (4). Hwang et al emphasized that a SPT may be classified as benign or malignant based on various criteria, including the presence/extent of perineural invasion, angioinvasion, capsular invasion, lymph node involvement, adjacent organ invasion and distant metastases (4). Rupture and metastasis of the tumor are the primary causes of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Traumatic rupture of solid pseudopapillary tumors of the pancreas in children: A case report

Mirapoğlu

Aydoğdu

Güçin

et al. 2016

Molecular and Clinical Oncology

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Abstract. Solid pseudopapillary tumor (SPT) of the pancreas is a pathological entity rarely encountered in children. Despite its malignant characteristics, SPT has a favorable clinical prognosis. This tumor is more frequently observed in females and is commonly localized in the tail and body of the pancreas. This is the case report of a 9-year-old female patient who presented with severe abdominal pain of sudden onset and vomiting following blunt abdominal trauma. Upon physical examination, abdominal distension, tenderness and abdominal guarding were detected. Abdominal magnetic resonance imaging revealed a mass sized 8x9x12 cm in the pancreas, with hemorrhagic-necrotic areas, and abundant intra-abdominal fluid. Intra-abdominal exploration confirmed the presence of an abundant amount of intraperitoneal hemorrhagic fluid. A mass was identified, originating from the body and the tail of the pancreas, adherent to the mesentery of the colon and the hilum of the spleen, which had ruptured in its inferolateral side. The tumor was extirpated together with the spleen and the involved parts of the pancreas. Histopathological examination demonstrated a solid pseudopapillary tumor of pancreatic origin. The patient's postoperative course was uneventful, clinically as well as metabolically.

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Solid-pseudopapillary neoplasm of the pancreas in children: Can we predict malignancy?

Cited by 54 publications

References 17 publications

Radical resection and enucleation in Chinese adolescents with pancreatic tumors

Radical resection and enucleation in Chinese adolescents with pancreatic tumors

Pancreatic surgery for tumors in children and adolescents

Traumatic rupture of solid pseudopapillary tumors of the pancreas in children: A case report

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