Solid-pseudopapillary neoplasm (SPN) of the pancreas: an enigmatic entity

Vassos, Nikolaos; Agaimy, Abbas; Klein, Peter; Hohenberger, Werner; Croner, Roland S.

doi:10.1016/j.pan.2014.05.556

Cited by 42 publications

(101 citation statements)

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“…Preoperative diagnosis of SPTs is generally made by CT or MRI imaging. Typically the tumor shows a large, well circumscribed, heterogeneous mass with varying solid and cystic components, generally demarcated by a peripheral capsule and occasional calcifications [10, 11]. These findings, together with other clinical findings, such as age and sex, may be sufficient for a correct diagnosis, as in more half of our patients (Figure 1).…”

Section: Discussionmentioning

confidence: 70%

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Beltrame

Pozza

Bona

et al. 2016

Gastroenterology Research and Practice

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Aim of this study was to review the institutional experience of solid-pseudopapillary tumors of the pancreas with particular attention to the problems of preoperative diagnosis and treatment. From 1997 to 2013, SPT was diagnosed in 18 patients among 451 pancreatic cystic neoplasms (3.7%). All patients underwent preoperative abdominal ultrasound, computed assisted tomography, and tumor markers (CEA and CA 19-9) determinations. In some instances, magnetic resonance, positron emission tomography, and endoscopic ultrasound with aspiration cytology were performed. There were two males and 16 females. Serum CA 19-9 was slightly elevated in one case. Preoperative diagnosis was neuroendocrine tumor (n = 2), mucinous tumor (n = 2), and SPT (n = 14). Two patients underwent previous operation before referral to our department: one explorative laparotomy and one enucleation of SPT resulting in surgical margins involvement. All patients underwent pancreatic resection associated with portal vein resection (n = 1) or liver metastases (n = 1). One patient died of metastatic disease, 77 months after operation, and 17 are alive and free with a median survival time of 81.5 months (range 36–228 months). Most of SPT can be diagnosed by CT or MRI, and the role of other diagnostic tools is very limited. We lack sufficient information regarding clinicopathologic features predicting prognosis. Caution is needed when performing limited resection, and long and careful follow-up is required for all patients after surgery.

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Section: Discussionmentioning

confidence: 70%

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Beltrame

Pozza

Bona

et al. 2016

Gastroenterology Research and Practice

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“…Solid pseudopapillary tumor of the pancreas was first described by Dr. Virginia Frantz in 1959 and later the World Health Organization (WHO) in 1996 defined the tumor as a low grade malignant neoplasm of the exocrine pancreas [1]. The tumor currently represents only 1-2% of exocrine pancreatic tumors and has rarely been recorded in elderly females, such as our patient, initially diagnosed at 78 years old.…”

Section: Discussionmentioning

confidence: 88%

“…The tumor currently represents only 1-2% of exocrine pancreatic tumors and has rarely been recorded in elderly females, such as our patient, initially diagnosed at 78 years old. Often an incidental finding, it can be associated with abdominal discomfort/pain, a palpable mass, anorexia, nausea, vomiting, and weight loss [1]. The etiology of SPTP is unknown; however it has been postulated to derive from either primitive pancreatic cells or cell lines of the female genital bud [3].…”

Section: Discussionmentioning

confidence: 99%

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Recurrence of Solid Pseudopapillary Tumor: A Rare Pancreatic Tumor

Punch

Garg

Harris

2016

Case Reports in Oncological Medicine

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Solid pseudopapillary tumor of the pancreas (SPTP) is a rare disease of young females that does not usually recur after resection. Here we report a case of an elderly female with history of SPTP ten years ago who presented with anorexia and a palpable left lower quadrant abdominal mass. Imaging revealed metastatic disease and US-guided biopsy of the liver confirmed the diagnosis of SPTP. Due to her advanced age and comorbidities, she elected to undergo hospice care. The objective of this case report is to increase awareness of this tumor and its possibility of recurrence, necessitating further guidelines for follow-up.

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“…6 Most SPNs are benign in nature with malignancy occurring rarely. 7 Of note, a single literature review found that 66 of the 452 cases evaluated demonstrated malignancy with regional metastasis. 8 Given the chance of malignancy, surgical resection of the tumor along with accompanying pancreatectomy, splenectomy, or pancreatico-duodenectomy is the course of treatment for SPNs.…”

Section: Pathologymentioning

confidence: 99%

Solid Pseudopapillary Neoplasm of the Pancreas in a Pediatric Patient

Stanley

Ciambotti

et al. 2015

Journal of Diagnostic Medical Sonography

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Solid pseudopapillary neoplasm (SPN) is a rare epithelial neoplasm of the pancreas, with low malignant potential, that usually occurs in young women. With advancing diagnostic imaging techniques and technology, the number of documented SPN cases has increased. Due to a varying morphologic appearance, SPNs often fail to show typical imaging findings, making it difficult to establish a definitive diagnosis. A case is reported of a SPN discovered on a routine abdominal sonogram, further characterized with magnetic resonance imaging, and confirmed with surgical pathology analysis. Sonographers should be aware of this rare pathology and should consider SPN in the differential diagnosis when encountering an indeterminate pancreatic neoplasm, especially in a young female patient.

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Solid-pseudopapillary neoplasm (SPN) of the pancreas: an enigmatic entity

Cited by 42 publications

References 0 publications

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience

Recurrence of Solid Pseudopapillary Tumor: A Rare Pancreatic Tumor

Solid Pseudopapillary Neoplasm of the Pancreas in a Pediatric Patient

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