Solid‐pseudopapillary tumours of the pancreas: 14 years experience

Sun, Ciluan-Dong; Lee, Woo Jung; Choi, Jin-Suob; Oh, Jung Tak; Choi, Seunghoon

doi:10.1111/j.1445-2197.2005.03488.x

Cited by 54 publications

(50 citation statements)

References 17 publications

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“…1,16,18 Considering the favourable outcome, most current recommendations support aggressive management, targeting complete resection of both the primary tumour and the metastatic lesions whenever possible. 6,16,19 Pancreatic duct dilation was present in four of eight SPC patients in the present study. Furthermore, all four of these mass lesions, which were located in the pancreatic head, showed distal pancreatic ductal dilation.…”

Section: Discussionsupporting

confidence: 51%

Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI

Lee

Kim

et al. 2008

Clinical Radiology

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Section: Discussionsupporting

confidence: 51%

Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI

Lee

Kim

et al. 2008

Clinical Radiology

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“…This trend can be seen in our study, for example, 27 of 34 (79.4%) patients were diagnosed after the year 2000. Large single-institutional reports of SPN diagnoses after 2005 are summarized in table 4 [7,8,9,13,20,21,22,23,24,25,26,27,28,29,30,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Suzuki¹,

Hatori²,

Furukawa

et al. 2014

Dig Surg

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Aims: The aim of this study was to determine the clinicopathological features and surgical management of solid pseudopapillary neoplasms (SPNs) of the pancreas at a single institution. Methods: We investigated 34 patients (5 males and 29 females) who underwent surgery for pathologically confirmed SPNs between 1994 and 2012. Results: Clinical symptoms were absent in 58.8% of the patients. The median tumor diameter was 42.7 mm. All tumors were successfully removed by R0 resection. Pathologically, 5.9% had duodenum invasion and 2.9% had pancreatic serosal invasion, but there was no lymph node metastasis. Radiological findings showed calcification in 39.4% of the patients, capsule formation in 51.5%, cystic components in 69.7%, solid components in 93.9% and internal bleeding in 36.4%. Immunohistochemically, neuron-specific enolase was positive in 100% of the patients, nuclear accumulation of β-catenin in 100% and CD10 in 78.8%. There were no recurrences reported at the median follow-up (67 months). Regarding gender differences, the cystic component in radiological imaging was the only significant finding among the features studied (p = 0.01). Conclusions: R0 resection with appropriate procedures appears to be sufficient for patients with SPNs, even for locally invasive tumors. There were no significant differences between genders except for the cystic component on radiological imaging.

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“…From the biological, molecular and oncological point of view, it represents and "enigmatic" tumor from which the origin, prognostic factors and natural history are unknown, having aroused a great interest and awareness in the last decades, when several clinical series and excellent reviews have been reported (4,(8)(9)(10)(11)13,(15)(16)(17)(22)(23)(24)(25)(26).…”

Section: Methodsmentioning

confidence: 99%

Solid pseudopapillary tumor of the pancreas (SPPT): Still an unsolved enigma

Cienfuegos

Lozano

Rotellar

et al. 2010

Rev. esp. enferm. dig.

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Solid pseudo-papillary tumor (SPPT) is a rare cystic tumor of the pancreas (1-3% of exocrine tumors of the pancreas) which shows an "enigmatic" behavior on the clinical and molecular pattern. A retrospective analysis of the citological studies and resected specimens of pancreatic cystic tumors from May 1996 to February 2010 was carried out. Three cases of SPPT were found, which are the objective of this study. The diagnosis was established upon occasional finding in the abdominal CT, in spite of sizing between 3 and 6 cm of diameter. In the three cases the preoperative diagnosis was confirmed by citology and specific immunohistochemical staining. Cases 2 and 3 showed strong immunoreactivity for Beta-Catenina and E-Cadherina staining. Radical resection (R0) was carried out in the three cases. A young male -21 years of age (case 1)-who had duodenal infiltration and two lymph nodes metastases died of hepatic and peritoneal recurrence 20 months following surgery. The other two cases are free of disease. The current review of the literature reports roughly 800 cases since the first report in 1959, and shows the enigmatic character of this tumor regarding the cellular origin, molecular pathways, prognostic factors and clinical behavior.Key words: Solid-pseudopapillary tumor. Pancreatic cystic neoplasm. Prognosis. Beta-catenina. RESUMENEl tumor pseudopapilar (TSPP) es un tumor quístico del pán-creas muy poco frecuente (1-3% de los tumores exocrinos del páncreas) y que tiene un comportamiento oncológico y molecular "enigmático". Se realizó un análisis retrospectivo de las citologías de las lesiones quísticas del páncreas, así como de los tumores quísticos resecados entre mayo de 1996 y febrero de 2010, encontrándose tres tumores SSPP, motivo de este estudio. En los tres casos el diagnóstico fue ocasional en el TC abdominal a pesar de presentar unos tamaños entre 3 y 6 cm de diámetro. En los tres casos se confirmó el diagnóstico preoperatorio mediante citología e inmunohistoquímica. En los casos 2 y 3 se confirmó la positividad para Beta-Catenina y E-Cadherina. En todos los casos se realizó cirugía radical (R0). Un varón de 21 años -caso 1-que presentaba infiltración duodenal y metástasis ganglionares falleció de progresión hepática y peritoneal a los veinte meses de la cirugía. Las otras dos pacientes -casos 2 y 3-se encuentran libres de recidiva. La revisión de la literatura desde su descripción en 1959 hasta la actualidad -aproximadamente 800 casos-confirma el carácter enigmático de este tumor en relación a su origen celular, molecular, factores pronósticos y comportamiento clínico.Palabras clave: Tumor sólido-pseudopapilar, Tumores quísti-cos de páncreas. Pronóstico.

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Solid‐pseudopapillary tumours of the pancreas: 14 years experience

Abstract: Symptoms of SPTP are indistinct and preoperative diagnosis is often inaccurate. Magnetic resonance imaging improves SPTP diagnosis. In general, the prognosis of well-circumscribed SPTP is favourable after curative resection.

Cited by 54 publications

References 17 publications

Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI

Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Solid pseudopapillary tumor of the pancreas (SPPT): Still an unsolved enigma

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