Solid Sampling with a Diode Laser for Portable Ambient Mass Spectrometry

Yung, Yeni P; Wickramasinghe, Raveendra C.; Vaikkinen, Anu; Kauppila, Tiina J.; Veryovkin, I. V.; Hanley, Luke

doi:10.1021/acs.analchem.7b01745

Cited by 12 publications

(12 citation statements)

References 36 publications

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“…77 New developments in laser-based ambient ionization MS techniques have also focused on integrations of laser ablation with various postionization methods other than ESI. These methods include laser diode thermal desorption coupled to atmospheric pressure photoionization (LDTD-APPI), 78 laserinduced acoustic desorption-atmospheric pressure photoionization (LIAD-APPI), 63 and laser ablation-aerosol mass spectrometry-chemical ionization mass spectrometry (LA-AMS-CIMS). 79 Of these, both LDTD-APPI and LIAD-APPI utilize photoionization as the ionization method, a process in which high energy UV photons interact with and ionize neutral gas-phase molecules that present low ionization potentials, such as low-polarity molecules.…”

mentioning

confidence: 99%

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

et al. 2019

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confidence: 99%

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

et al. 2019

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“…Diode lasers have also been evaluated as a means of sample desorption for AIMS applications. Diode lasers are compact, cost‐effective and do not require a high power input to operate, thus, are well suited to use in ion sources intended for use outside of the laboratory 24 . Techniques employing diode lasers operate in a similar fashion to LAESI, directing the laser at the sample surface to induce ablation prior to ionization by an electrospray plume.…”

Section: Ambient Ionization Ms Techniquesmentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

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Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

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“…New versions of instrument design and widespread applications continue to appear since the original report of LA‐APPI. A variant of this method utilizing a CW diode laser at 940 nm for sample desorption and a 10.0/10.6 eV VUV lamp for ionization has been illustrated by connecting to a field‐deployable ion trap MS for the detection of sage leaves and grown biofilms of Pseudomonas aeruginosa (Yung et al, 2017). To differentiate with previously described LA‐APPI, this approach is called laser diode thermal desorption atmospheric pressure photoionization (LDTD‐APPI) because of the use of a low‐cost and battery‐powered diode laser.…”

Section: La‐appi In Bioapplicationsmentioning

confidence: 99%

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

Ding

Liu

Shi

2020

Mass Spectrometry Reviews

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Lasers have long been used in the field of mass spectrometric analysis for characterization of condensed matter. However, emission of neutrals upon laser irradiation surpasses the number of ions. Typically, only one in about one million analytes ejected by laser desorption/ablation is ionized, which has fueled the quest for postionization methods enabling ionization of desorbed neutrals to enhance mass spectrometric detection schemes. The development of postionization techniques can be an endeavor that integrates multiple disciplines involving photon energy transfer, electrochemistry, gas discharge, etc. The combination of lasers of different parameters and diverse ion sources has made laser desorption/ablation postionization (LD/API) a growing and lively research community, including two‐step laser mass spectrometry, laser ablation atmospheric pressure photoionization mass spectrometry, and those coupled to ambient mass spectrometry. These hyphenated techniques have shown potentials in bioanalytical applications, with major inroads to be made in simultaneous location and quantification of pharmaceuticals, toxins, and metabolites in complex biomatrixes. This review is intended to provide a timely comprehensive view of the broadening bioanalytical applications of disparate LD/API techniques. We also have attempted to discuss these applications according to the classifications based on the postionization methods and to encapsulate the latest achievements in the field of LD/API by highlighting some of the very best reports in the 21st century. © 2020 John Wiley & Sons Ltd.

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Solid Sampling with a Diode Laser for Portable Ambient Mass Spectrometry

Cited by 12 publications

References 36 publications

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

Applications of ambient ionization mass spectrometry in 2021: An annual review

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

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