Solid Self Nano Emulsifying Drug Delivery System (Solid Snedds) of Mefenamic Acid: Formula Optimization Using Aerosil®-200 and Avicel® Ph-101 With Factorial Design

Abstract

Self-nanoemulsifying drug delivery system (SNEDDS) is capable of enhancing the solubility of class II BCS drugs with low solubility in water such as mefenamic acid. This system facilitates the process of solubilization to spontaneously occur in the digestive tract with little agitation. Solid SNEDDS is a form of SNEDDS solidification developed to overcome the stability problems which inhibits SNEDDS ease of use. Solid SNEDDS of mefenamic acid was performed using adsorption method on porous carriers aerosil ® -200 and avicel ® PH-101. Factorial design was utilized to determine the influence of carrier and proportion of carrier to liquid form of SNEEDS. The acquired solid SNEDDS retained excellent drug content yield with a value of 100.355% along with favorable good flow and compressibility properties. Morphology analysis with SEM indicates the porous carrier was capable in completely adsorbing SNEDDS on the surface while maintaining the physical form. Solid SNEDDS was able to significantly increase the dissolution of mefenamic acid which can be seen from higher percent dissolution efficiency values (43.925 ± 0.5) % compared with generic tablets (17.865 ± 0.058 )% and capsules containing pure mefenamic acid (9.396 ± 0.009)%. Analysis of stability using various temperatures demonstrated the ability of solid SNEDDS to protect the content of mefenamic acid leading to better stability. Additionally, FTIR analysis did not show any interaction between the optimum formula components of solid SNEDDS. These results conclude that aerosil ® -200 and avicel ® PH-101 was able to act as a solid porous carrier of SNEDDS while simultaneously improving dissolution and stability.