Solid Solubilities of Sulfonamides and Use of Rapid Expansion of Supercritical Solutions for Microparticle Production

Abstract

The solubility of solid active pharmaceutical ingredients in supercritical fluids is a major thermodynamic criterion for selection and screening of microparticle generation processes. To develop an efficient method for solubility prediction, a solution model was adopted to establish the correlations of the solid solubilities of six sulfonamides in supercritical CO 2 . The model was capable of determining solubility correlations. Accordingly, it was attempted to simplify and generalize the model, yielding a predictive solution model, which provided order-consistent solubility predictions. A case study for model extrapolation was conducted. After understanding the mechanisms underlying the solubility of sulfonamides, the rapid expansion of supercritical solutions (RESS) process was applied to produce microparticles of p-toluenesulfonamide, an anticancer drug. The effects of RESS process parameters were investigated.

Behavior of beeswax and edible oils mixtures in supercritical carbon dioxide at moderate temperature

“…In this technique the supercritical CO 2 dissolves in a melted lipid or plasticized polymer, and the rapid expansion of the solution through a nozzle results in precipitated particles (Akbari et al, 2020). In the RESS process, supercritical CO 2 is used as a means to extract the target material at high pressure; subsequently, the supercritical solution is depressurized to achieve high supersaturation for the generation of fine particles (Yang et al, 2020). Neither RESS nor PGSS uses organic solvents.…”

Estudo da formação de micropartículas fitoterápicas contendo extrato de folhas de >i<Cynara cardunculus>/i< L. por tecnologia supercrítica e por gelificação iônica para emprego no desenvolvimento de >i<sorbet>/i< funcional

“…Esta técnica consiste na saturação do material de interesse com CO 2 supercrítico, seguida por expansão através de um bico aspersor Münüklü, Jansens, 2007). No processo RESS, o CO 2 supercrítico é usado como meio de extrair o material alvo em alta pressão; posteriormente, a solução supercrítica é despressurizada para atingir alta supersaturação para a geração de partículas finas (Yang et al, 2020). A tecnologia com fluido supercrítico apresenta várias vantagens, por exemplo, ao usar RESS e PGSS, existe a possibilidade de impregnar as partículas sem o uso de água ou solventes orgânicos, além do potencial para aplicação de uma ampla gama de produtos devido à variação da densidade do fluido supercrítico em função da pressão.…”