Solid-state characterization and pharmaceutical compatibility between citalopram and excipients using thermal and non-thermal techniques

Pires, Stephany; Mussel, Wagner da Nova; Yoshida, María Irene

doi:10.1007/s10973-016-5769-z

Cited by 8 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The shifts on RA signals in BMs suggest that some perturbation is occurring due to the presence of excipients. According to Pires et al (2017) these perturbations are not considered incompatibilities, due to the fact shifts are lower than 1 ppm; thus, this could be promoted by physical interaction, most specifically, adsorption effect. Besides, no unexpected signals appeared in spectra, suggesting chemical compatibility, corroborating with FTIR data.…”

Section: Resultsmentioning

confidence: 99%

“…Several techniques have been applied in compatibility studies with excipients, such as differential scanning calorimetry (DSC), thermogravimetry (TG), Fourier-transform infrared (FTIR), X-ray diffraction (XRD), solid-state nuclear magnetic resonance (ssNMR) and isothermal stress testing (IST) coupled with liquid chromatography (LC) (Chadha and Bhandari, 2014). Some of these techniques are more commonly used due to fast analyses, low material consumption, and the ability to detect impurities/degradation products (Chadha and Bhandari, 2014, Pires et al, 2017, Rojek et al, 2013, Verma and Garg, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Veras

Fachel

Pittol

et al. 2019

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Rosmarinic acid (RA) is a phenolic compound that presents well-documented anti-inflammatory, antioxidant and antitumor activities, and based on its pharmacological potential and poor bioavailability, several solid dosage forms have been developed to RA delivery. Therefore, in literature, there are no reports about RA compatibility with excipients. In this regard, the aim of the present study was to evaluate, for the first time, the compatibility of RA with excipients commonly used in solid dosage forms at a 1:1 (RA:excipient) ratio using differential scanning calorimetry (DSC), thermogravimetry (TG), Fourier-transform infrared (FTIR), solid-state nuclear magnetic resonance (ssNMR), and isothermal stress testing (IST) coupled with liquid chromatography (LC). The excipients selected were hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), lactose monohydrate (LAC), polyvinylpyrrolidone (PVP), talc (TALC), croscarmellose sodium (CCS), and magnesium stearate (MgSTE). According to DSC results, physical interactions were found between RA and HPMC, LAC, CCS, and MgSTE. The TG analyses confirmed the physical interactions and suggested chemical incompatibility. FTIR revealed physical interaction of RA with TALC and MgSTE and the ssNMR confirmed the physical interaction showed by FTIR and excluded the presence of chemical incompatibility. By IST, the greatest loss of RA content was found to CCS and MgSTE (>15%), demonstrating chemical incompatibilities with RA. High temperatures used in DSC and TG analyses could be responsible for incompatibilities in binary mixtures (BMs) with HPMC and LAC, while temperature above 25 °C and presence of water were factors that promote incompatibilities in BMs with CCS and MgSTE. Overall results demonstrate that RA was compatible with MCC and PVP.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Veras

Fachel

Pittol

et al. 2019

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…Međutim, zbog zagrijavanja uzoraka na visoke temperature, često dolazi do interakcija koje se u stvarnim uvjetima ne bi dogodile, stoga zaključke donesene na temelju termoanalitičkih mjerenja treba potvrditi primjenom drugih komplementarnih tehnika poput onih spektroskopskih ili uvođenjem drugih studija. 43,49,50 Sastavnica 1 Fizikalno-kemijska karakterizacija Fizikalno-kemijska karakterizacija Smjesa sastavnica Usporedba Fizikalno-kemijska karakterizacija Sastavnica 2 Slika 2 -Shema provedbe ispitivanja fizikalno-kemijske kompatibilnosti sastavnica Fig. 2 -Scheme describing principle of physicochemical compatibility determination…”

Section: Termalne Tehnikeunclassified

Ispitivanje fizikalno-kemijske kompatibilnosti lijekova primjenom analitičkih tehnika: pregled istraživanja razvoja fiksne kombinacije 5-aminosalicilata i folne kiseline

Jeličić

2022

Kemija U Industriji

View full text Add to dashboard Cite

With the use of fixed-dose drug combinations, the potential risk of non-adherence needs to be minimised, which is particularly important in patients with chronic diseases. The development of such dosage form is a complex process in which an important role is played by testing the physicochemical compatibility of the components intended for the manufacture of the desired product. Various analytical techniques, such as thermoanalytical (DSC, DTA), spectroscopic (FTIR, XRPD) and chromatographic (HPLC), in combination with certain degradation studies, such as forced degradation and isothermal degradation, are often used. In this review, on the example of the development of a fixed-dose combination of 5-aminosalicylate and folic acid, procedures suitable for testing the compatibility of drug components, as well as analytical techniques and various ways of interpretation of results are described.

show abstract

Encapsulation study of citalopram and risperidone into nanostructured silica SBA-15 for in vitro release evaluation

Tanaka

Santos

Gouveia

et al. 2017

J Therm Anal Calorim

View full text Add to dashboard Cite

Solid-state characterization and pharmaceutical compatibility between citalopram and excipients using thermal and non-thermal techniques

Cited by 8 publications

References 17 publications

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Ispitivanje fizikalno-kemijske kompatibilnosti lijekova primjenom analitičkih tehnika: pregled istraživanja razvoja fiksne kombinacije 5-aminosalicilata i folne kiseline

Encapsulation study of citalopram and risperidone into nanostructured silica SBA-15 for in vitro release evaluation

Contact Info

Product

Resources

About