Solid State Electrochemical Oxidation of Some Bisphosphoramidates in Aqueous Media and their Applications in DNA Sensing

Abstract

Bisphosphoramidates are known as anticancer, antibacterial, antiviral drugs and enzyme inhibitory agents. These compounds are electroactive and insoluble in aqueous media. Hence, a comprehensive study about the electrochemical properties of them seems very interesting. The oxidative behaviors of some bisphosphoramidates were studied in buffer solution over a wide pH range by cyclic voltammetry and differential pulse voltammetry using spiked carbon paste electrodes. The interaction of these compounds with calf thymus DNA (CT‐DNA) showed the ability of these compounds as DNA sensing. The decrease in the anodic peaks of bisphosphoramidates in the presence of DNA was used for the DNA monitoring.

Lead(II) ion selective poly(aniline) solid contact electrode based on 1,2-bis(N′-benzoylthioureido)ethane, -propane and -butane ionophores

“…Crown ethers and calixarenes have been found selective for lead ions and used to prepare highly selective elec trodes for lead ions: 1,10 dibenzyl 1,10 diaza 18 crown 6 [15], 4' vinylbenzo 15 crown 5 homopoly mer [16], calix [4]arene derivative [17,18], calixarene carboxyphenyl azo derivative [19], phosphorylated calix [4]arene derivative [20], phosphorate functional ized caly [4]arenas [21], p tert buthylcalix [4]arene de rivative [22], a substituted azacrown [23] have also been successfully used as electroactive materials to de velop ISEs for lead. 2,2' Dithiodibenzoic acid [24], 5,5' dithiobis(2 nitrobenzoic acid) [25], polyaminoan thraquinone [26], 1 furoil 3,3 diethylthiourea [27], 2 (((E) 2 ((E) 1 (2 hydroxyphenyl)methyliden)hydra zo no)methyl) phenol [28], N,N' bisthiophen 2 ylme thylene pyridine 2,6 diamine [29], N,N' bisthiophene 2 ylmethylene ethane 1,2 diamine [30], N,N diben zyl 1,4,10,13 tetraoxa 7,16 diaza cyclooctadecane [31], dimethylene bis(4 methylpiperidine dithiocar bamate) [32] have also been used as electroactive ma terials in lead ISEs. However, these sensors exhibit narrow working concentration ranges, high response time and suffer interference from some metal ions.…”