Solid-state interactions and drug release of teicoplanin in binary combinations with peracetylated α-, β-, and γ-cyclodextrins

Bettinetti, Giampiero; Sorrenti, Milena; Catenacci, Laura; Ferrari, Franca; Rossi, Silvia; Salvadeo, Ilaria; Carraro, Paolo

doi:10.1007/s10847-006-9182-2

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…In particular, in β-CD derivatives, the introduction of substituent on hydroxyl groups such as hydroxypropyl (HP-β-CD), methyl (heptakis(2,6-di-O-methyl)-β-CD (DM-β-CD), and randomly methylated β-CD (RM-β-CD)) and sulfobutylether sodium salt (SBE-β-CD) improved its aqueous solubility and toxicological profile. On the other hand, hydrophobic CD derivatives such as triacetyl CDs can be used as excipients to sustain and control the release of water-soluble drugs [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

et al. 2021

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Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipients, as solubilizers and absorption promoters, and as active ingredients due to their several biological activities (antiviral, antiparasitic, anti-atherosclerotic, and neuroprotective). The use of CDs in nasal formulations allowed obtaining versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. In vitro and in vivo models currently employed are suitable to analyze the effects of CDs in nasal formulations. Therefore, CDs are versatile pharmaceutical materials, and due to the continual synthesis of new CDs derivatives, the research on the new nasal applications is an interesting field evolving in the coming years, to which Italian research will still contribute.

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Section: Introductionmentioning

confidence: 99%

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

et al. 2021

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“…Therefore, in the last years, the use of γ-cyclodextrin has grown for applications involving large guests like DNA, 12 surfactants, 13 and polymers 14,15 and, in general, in the pharmaceutical and biomedical fields. [16][17][18] Diffusion coefficients for some aqueous cyclodextrin solutions at 298.15 K have been reported, [19][20][21][22] but as far as the authors know, no data on mutual diffusion coefficients of γ-cyclodextrin for the same concentrations at (298.15 and 310.15) K for in vivo pharmaceutical applications are available. We are particularly interested in data on the diffusion and on the viscosity of γ-cyclodextrin in aqueous solutions, especially at the physi-ological temperature and in a low concentration range, correspondingly to the therapeutic dosage.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, complex formation involving γ-cyclodextrin is not a favorable process because it has a large cavity volume (510 Å 3 ) when compared with those for α- and β-cyclodextrin [(176 and 346) Å 3 , respectively]. Therefore, in the last years, the use of γ-cyclodextrin has grown for applications involving large guests like DNA, surfactants, and polymers , and, in general, in the pharmaceutical and biomedical fields. – …”

Section: Introductionmentioning

confidence: 99%

Some Transport Properties of γ-Cyclodextrin Aqueous Solutions at (298.15 and 310.15) K

et al. 2008

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Values of binary mutual diffusion (interdiffusion) coefficients, obtained by using the Taylor dispersion method, for aqueous solutions of γ-cyclodextrin in the concentration range from (0.002 to 0.010) mol · dm -3 and temperatures (298.15 and 310.15) K are reported. From these experimental results, the hydrodynamic radius values for the γ-cyclodextrin are estimated. Also, the measured diffusion coefficients are used with both Hartley's and Gordon's equations to estimate activity coefficients for aqueous γ-cyclodextrin. These studies are complemented by some density and viscosity measurements, carried out at the same range of concentrations and temperatures. The effect of both the viscosity of the medium and the formation of γ-cyclodextrin dimers on the estimated hydrodynamic radius is discussed.

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“…Teicoplanin , like vancomycin, has been combined with triacetyl-α-, -β-, or -γ-CD to prolong the release of this hydrophilic drug [ 241 ]. Triacetyl-γ-CD slowed down the release of the drug the most and, unexpectedly, the physical mixture preparation technique was found to be more effective in delaying the drug release than kneading and evaporative crystallisation under microwave irradiation.…”

Section: Other Antibacterial Drugsmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

Boczar

Michalska

2022

Pharmaceutics

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Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic surface, which allows the formation of inclusion complexes with various molecules. This review article summarises over 200 reports published by the end of 2021 that discuss the complexation of CDs with antibiotics and antibacterial agents, including beta-lactams, tetracyclines, quinolones, macrolides, aminoglycosides, glycopeptides, polypeptides, nitroimidazoles, and oxazolidinones. The review focuses on drug-delivery applications such as improving solubility, modifying the drug-release profile, slowing down the degradation of the drug, improving biological membrane permeability, and enhancing antimicrobial activity. In addition to simple drug/CD combinations, ternary systems with additional auxiliary substances have been described, as well as more sophisticated drug-delivery systems including nanosponges, nanofibres, nanoparticles, microparticles, liposomes, hydrogels, and macromolecules. Depending on the desired properties of the drug product, an accelerated or prolonged dissolution profile can be achieved when combining CD with antibiotics or antimicrobial agents.

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Solid-state interactions and drug release of teicoplanin in binary combinations with peracetylated α-, β-, and γ-cyclodextrins

Cited by 4 publications

References 4 publications

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

Some Transport Properties of γ-Cyclodextrin Aqueous Solutions at (298.15 and 310.15) K

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

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