Solid-State NMR Characterization of High-Loading Solid Solutions of API and Excipients Formed by Electrospinning

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

“…For pharmaceutical applications, electrospun polymer-based fibers have been investigated for providing different types of controlled drug release profiles, such as immediate, pulsatile, delayed, sustained, and biphasic releases (7)(8)(9)(10). Among them, sustained drug release is gaining considerable attention as a method of administering and maintaining desired drug concentrations in the blood within a specified therapeutic window, or in target tissues within a desired duration of drug delivery (11)(12)(13).…”

Structural Characterization of Amorphous Solid Dispersions

“…On-line monitoring of solid-state phase transformations in dry or suspended samples during manufacturing (e.g., by hot melt extrusion) Monitoring solid-and solution-mediated transformations (e.g., nucleation, crystallization) during dissolution of ASD API active pharmaceutical ingredient, FTIR Fourier transform infrared spectroscopy, NIR near-infrared spectroscopy, PAT process analytical technology, THz terahertz Table 14.6 Structural characterization of ASD by solid-state nuclear magnetic resonance (SS-NMR) spectroscopy and relaxometry and possible hurdles Molecular mobility (Apperley et al 2005;Aso et al 2000;Benmore et al 2013;Carpentier et al 2006;Geppi et al 2008;Ito et al 2010) Miscibility and drug-polymer interaction (Aso and Yoshioka 2006;Aso et al 2002Aso et al , 2007Aso et al , 2009Brettmann et al 2012a, b;Chen et al 2005;Forster et al 2003;Geppi et al 2008;Klama 2010;Pham et al 2010;Tatton et al 2013;Vogt et al 2011Vogt et al , 2013 Crystallinty/crystallization (Aso et al 2009;…”

“…F T Benmore et al 2013;Carpentier et al 2006;Geppi et al 2008;Ito et al 2010) Miscibility and drug-polymer interaction (Aso and Yoshioka 2006;Aso et al 2002Aso et al , 2007Aso et al , 2009Brettmann et al 2012a, b;Chen et al 2005;Forster et al 2003;Geppi et al 2008;Klama 2010;Pham et al 2010;Tatton et al 2013;Vogt et al 2011Vogt et al , 2013 Crystallinty/crystallization (Aso et al 2009;Dahlberg et al 2011;Geppi et al 2008;Offerdahl et al 2005;Seliger and Žagar 2013;Urbanova et al 2013;Vogt and Williams 2012;…”

Amorphous Solid Dispersions

“…On-line monitoring of solid-state phase transformations in dry or suspended samples during manufacturing (e.g., by hot melt extrusion) Monitoring solid-and solution-mediated transformations (e.g., nucleation, crystallization) during dissolution of ASD API active pharmaceutical ingredient, FTIR Fourier transform infrared spectroscopy, NIR near-infrared spectroscopy, PAT process analytical technology, THz terahertz Table 14.6 Structural characterization of ASD by solid-state nuclear magnetic resonance (SS-NMR) spectroscopy and relaxometry and possible hurdles Molecular mobility (Apperley et al 2005;Aso et al 2000;Benmore et al 2013;Carpentier et al 2006;Geppi et al 2008;Ito et al 2010) Miscibility and drug-polymer interaction Aso et al 2002Aso et al , 2007Aso et al , 2009Brettmann et al 2012a, b;Chen et al 2005;Forster et al 2003;Geppi et al 2008;Klama 2010;Pham et al 2010;Tatton et al 2013;Vogt et al 2011Vogt et al , 2013 Crystallinty/crystallization (Aso et al 2009;Dahlberg et al 2011;…”