Solid-state NMR study of fluorinated steroids

Yang, Kai-Jay; Lin, Shio Jean; Huang, Shing-Jong; Ching, Wei-Min; Hung, Chen‐Hsiung; Tzou, Der‐Lii M.

doi:10.1016/j.steroids.2013.11.020

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“…Creams, ointments, lotions, gels, and drops containing betamethasone, a fluorinated glucocorticoid , are widely used mainly at 0.05–0.13% (cca. 1–2 mM) concentrations to medicate various dermatological and eye diseases.…”

Section: Introductionmentioning

confidence: 99%

Betamethasone augments the antifungal effect of menadione—towards a novel anti‐Candida albicans combination therapy

Jakab

Emri

Sipos

et al. 2015

J. Basic Microbiol.

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The fluorinated glucocorticoid betamethasone stimulated both the extracellular phospholipase production and hypha formation of the opportunistic human pathogen Candida albicans and also decreased the efficiency of the polyene antimycotics amphotericin B and nystatin against C. albicans in a dose-dependent manner. Importantly, betamethasone increased synergistically the anti-Candida activity of the oxidative stress generating agent menadione, which may be exploited in future combination therapies to prevent or cure C. albicans infections, in the field of dermatology.

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Section: Introductionmentioning

confidence: 99%