Solid-state ultra-wideband pulse generator: Application in bioeffect research

Abstract

This article describes the design and characterization of an ultra-wideband (UWB) pulse generator suitable for biomedical research. The pulser generates nanosecond-long electromagnetic pulses of adjustable rise time, amplitude, and duration, permitting analysis of possible bioeffects over a range of pulse characteristics. Nanosecond rise-time pulses (2.4 ns) of 3.4 kV are achieved in a four-stage pulser circuit using ZTX415 transistors. This device has been used to assess exposure bioeffects to UWB pulses of the model system E. coli.

Effect of electromagnetic nanopulses onC. elegans fertility

“…In this context we have also investigated nanopulse production [Sunkam et al, 2005] and computational approaches to characterizing nanopulse propagation in biological matter Su et al, 2005]. Three broad classes of model have been selected for experimental study: macromolecules (manuscript in preparation), proliferative cells [Dorsey et al, 2005;Sylvester et al, 2005] and non-proliferative cells (manuscript in preparation), and whole organisms (the present report).…”