Solid‐Supported Synthesis

Yellol, Gorakh S.; Sun, Chung‐Ming

doi:10.1002/9780470711828.ch15

Cited by 4 publications

(1 citation statement)

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“…In this regard, we and others have recognized the usefulness of solid-supported olefin cross-metathesis for generation of biologically relevant molecules [ 27 , 28 , 29 , 30 , 31 ], including a comprehensive study to understand the process [ 32 , 33 ]. From the viewpoint of green chemistry, using solid-phase synthetic sequences allows a significant reduction in solvent waste, since purification is performed by phase separation, avoiding chromatographic isolation of products which requires a large consumption of organic solvents [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

2018

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The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.

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