Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel

Jiang, Xinyi; Xin, Hongliang; Gu, Jijin; Xu, Ximing; Xia, Weiyi; Chen, Shuo; Xie, Yike; Chen, Liangcen; Chen, Yanzuo; Sha, Xianyi; Fang, Xiaoling

doi:10.1016/j.biomaterials.2012.11.016

Cited by 93 publications

(69 citation statements)

References 29 publications

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“…45,46 This is supported by a recent publication. 47 The results from either of these spheroid models could be useful in relative studies comparing penetration of different NP delivery systems. However, we believe that the slower and lower penetration in the organotypic slices is much more representative of normal tissue in vivo.…”

Section: Discussionmentioning

confidence: 99%

Penetration and intracellular uptake of poly(glycerol-adipate) nanoparticles into three-dimensional brain tumour cell culture models

Meng

Garnett

Walker

et al. 2015

Exp Biol Med (Maywood)

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Nanoparticle (NP) drug delivery systems may potentially enhance the efficacy of therapeutic agents. It is difficult to characterize many important properties of NPs in vivo and therefore attempts have been made to use realistic in vitro multicellular spheroids instead. In this paper, we have evaluated poly(glycerol-adipate) (PGA) NPs as a potential drug carrier for local brain cancer therapy. Various three-dimensional (3-D) cell culture models have been used to investigate the delivery properties of PGA NPs. Tumour cells in 3-D culture showed a much higher level of endocytic uptake of NPs than a mixed normal neonatal brain cell population. Differences in endocytic uptake of NPs in 2-D and 3-D models strongly suggest that it is very important to use in vitro 3-D cell culture models for evaluating this parameter. Tumour penetration of NPs is another important parameter which could be studied in 3-D cell models. The penetration of PGA NPs through 3-D cell culture varied between models, which will therefore require further study to develop useful and realistic in vitro models. Further use of 3-D cell culture models will be of benefit in the future development of new drug delivery systems, particularly for brain cancers which are more difficult to study in vivo.

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Section: Discussionmentioning

confidence: 99%

Penetration and intracellular uptake of poly(glycerol-adipate) nanoparticles into three-dimensional brain tumour cell culture models

Meng

Garnett

Walker

et al. 2015

Exp Biol Med (Maywood)

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“…Poly(hydroxyalkanoates) (PHAs) and poly(carbonates) (PCs) have attracted considerable attention for the design of drug delivery systems due to their high biocompatibility and low toxicity (Furrer et al, 2008;Wu et al, 2009;Hazer, 2010;Hu et al, 2012;Shrivastav et al, 2013;Chen et al, 2014;Loyer and Cammas-Marion, 2014;Li and Loh, 2015;Nigmatullin et al, 2015). In this context, poly(3-hydroxybutyrate) and poly(trimethylene carbonate) have been developed to produce gels and matrices for tissue engineering (Shishatskaya et al, 2004 ;Asran et al, 2010 ;Song et al, 2011 ;Schüller-Ravoo et al, 2013 ;Rozila et al, 2016 ;Ding et al, 2016 ;Pascu et al, 2016 ;Zant et al, 2016) and NPs for drug delivery (Xiong et al, 2010 ;Jiang et al, 2013 ;Fukushima 2016 ;Pramual et al, 2016). Our laboratories have recently synthesized and characterized novel poly(hydroxyalkanoate)-based 7 amphiphilic diblock copolymers, namely poly(-malic acid)-b-poly(3-hydroxybutyrate) (PMLA-b-PHB) (Barouti et al, 2015) and poly(-malic acid)-b-poly(trimethylene carbonate) (PMLA-b-PTMC) (Barouti et al, 2016a), hydrophobic PMLA Be -b-PHB-b-PMLA Be and amphiphilic PMLA-b-PHB-b-PMLA triblock copolymers (Barouti et al, 2016b) as well as linear and star-shaped thermogelling poly([R]-3-hydroxybutyrate) copolymers (Barouti et al, 2016c).…”

mentioning

confidence: 99%

Opsonisation of nanoparticles prepared from poly(β-hydroxybutyrate) and poly(trimethylene carbonate)-b-poly(malic acid) amphiphilic diblock copolymers: Impact on the in vitro cell uptake by primary human macrophages and HepaRG hepatoma cells

Vène

Barouti

Jarnouen

et al. 2016

International Journal of Pharmaceutics

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The present work reports the investigation of the biocompatibility, opsonisation and cell uptake by human primary macrophages and HepaRG cells of nanoparticles (NPs) formulated from poly(-malic acid)-b-poly(-hydroxybutyrate) (PMLA-b-PHB) and poly(-malic acid)-b-poly(trimethylene carbonate) (PMLA-b-PTMC) diblock copolymers, namely PMLA800-b-PHB7300, PMLA4500-b-PHB4400, PMLA2500-b-PTMC2800 and PMLA4300-b-PTMC1400. NPs derived from PMLA-b-PHB and PMLA-b-PTMC do not trigger lactate dehydrogenase release and do not activate the secretion of pro-inflammatory cytokines demonstrating the excellent biocompatibility of these copolymer derived nano-objects. Using a protein adsorption assay, we demonstrate that the binding of plasma proteins is very low for PMLA-b-PHB-based nanoobjects, and higher for those prepared from PMLA-b-PTMC copolymers. Moreover, a more efficient uptake by macrophages and HepaRG cells is observed for NPs formulated from PMLA-b-PHB copolymers compared to that of PMLA-b-PTMC-based NPs. Interestingly, the uptake in HepaRG cells of NPs formulated from PMLA800-b-PHB7300 is much higher than that of NPs based on PMLA4500-b-PHB4400. In addition, the cell internalization of PMLA800-b-PHB7300 based-NPs, probably through endocytosis, is strongly increased by serum pre-coating in HepaRG cells but not in macrophages. Together, these data strongly suggest that the binding of a specific subset of plasmatic proteins onto the PMLA800-b-PHB7300-based NPs favors the HepaRG cell uptake while reducing that of macrophages.

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“…Their study demonstrated that the targeted NP had stronger drug distribution in tumor tissue and was more efficient at inhibiting tumor growth and neovascularization in vivo [164]. In another study, Jiang et al showed that integrinmediated poly(trimethylene carbonate)-based stealth NPs, c(RGDyK)-NP, loaded with paclitaxel had greater tumor penetration, accumulation, and growth inhibitory effect than other conventional NPs [167].…”

Section: Targeting the Tumor Vasculaturementioning

confidence: 96%

Nanomedicine—Nanoparticles in Cancer Imaging and Therapy

Hauser-Kawaguchi

Luyt

2014

Cancer Metastasis - Biology and Treatment

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Nanomedicine refers to the application of nanotechnology in medicine, and endeavors to diagnose, treat, and/or monitor disease on a nanoscale. Cancer nanotechnology is a quickly evolving field of interdisciplinary research that involves the biomedical application of nanoparticles, which are nanoscale devices that are able to overcome biological barriers, specifically recognize a single type of cancer cell, and accumulate preferentially in tumors. Medical applications with nanoparticles are growing, as they have the potential to offer novel methods of noninvasive cancer detection, diagnosis, and treatment. Tumor targeting ligands, such as antibodies, peptides, or small molecules, can be attached to nanoparticles for targeting of tumor antigens and vasculatures with high affinity and specificity. In addition, diagnostic agents (i.e. optical, radiolabels, or magnetic) and chemotherapeutic drugs can be integrated into their design for more efficient imaging and treatment of the tumor with fewer side effects. Recent advances in nanomedicine raise exciting possibilities for future nanoparticle applications in personalized cancer therapy.

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Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel

Cited by 93 publications

References 29 publications

Penetration and intracellular uptake of poly(glycerol-adipate) nanoparticles into three-dimensional brain tumour cell culture models

Penetration and intracellular uptake of poly(glycerol-adipate) nanoparticles into three-dimensional brain tumour cell culture models

Opsonisation of nanoparticles prepared from poly(β-hydroxybutyrate) and poly(trimethylene carbonate)-b-poly(malic acid) amphiphilic diblock copolymers: Impact on the in vitro cell uptake by primary human macrophages and HepaRG hepatoma cells

Nanomedicine—Nanoparticles in Cancer Imaging and Therapy

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