A new global movement that emerged as a post 2015 development agenda is the sustainable development goals (SDGs). While the central objective of SDGs is to end poverty in all its forms, focus on water and sanitation rested on the fundamental concern for equity; moving from just service delivery to service delivery for all. Hence, the study reported in this chapter was set to examine the state of households' environmental sanitation practices in different residential areas of Ile-Ife, Nigeria. A three-stage multi-sampling procedure was adopted in selecting 283 households' heads for survey. Findings of study showed that 23.6, 41.2, and 68.4% of households in the core, transition, and suburban residential areas of Ile-Ife, respectively, have source of water within their residential building. Study established that households' toilet facilities differ significantly in the study area, as respondents socioeconomic characteristics varied across the identified residential areas of Ile-Ife. The study thus posited that, if cities in Nigeria and other developing nations will keep tract with timelines of the SDGs on water and sanitation, drastic, and realistic steps must be taken in addressing identified inequalities. This is a way to guaranty adequate hygiene and improved quality of life.