Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method
Bao Ngoc Tran,
Hiep Tuan Tran,
Giang Thi Le
et al.
Abstract:The pharmaceutical industry has highlighted particle-size reduction via preparing aqueous suspensions containing nano- or submicron drug particles. Owing to the risk of agglomeration and complications during the manufacturing of solid dosage forms, the problems associated with the solidification of nanosuspensions need to be addressed. Herein, the nanocrystallized suspension of fenofibrate (Feno) was prepared using the wet-milling technique, and then two solidification methods, mixing (liquid mixing) and granu… Show more
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