Solitary Annular Plaque on the Scrotum

Clinicopathological, dermoscopic, and ultrastructural observation of annular secondary syphilis on the penis

“…5 The orangish background may originate from erythrocyte extravasation and hemosiderin deposition in the dermis. 6 However, regularly dotted vessels (typical hallmark of psoriasis) were observed in a case of annular scrotal plaque, 2 while Biett's collarette and orangish background were absent in our case. Therefore, although its diagnostic value is currently limited for secondary syphilis, dermoscopy is useful in the differential diagnosis with other common inflammatory dermatoses.…”

“…Annular syphilis is more common in children and black patients during the late secondary stage, and often involves the scalp, face, palm, sole, and intertriginous and genital regions. [1][2][3][4] Appearances may range from mildly raised lesions with scaly borders to verrucous plaques. 1 Localized annular syphilis on the genitalia has been rarely reported in HIV-negative cases, and should be distinguished from granuloma annulare, annular lichen planus, annular psoriasis, scabies, and dermatophytosis.…”

“…1 Localized annular syphilis on the genitalia has been rarely reported in HIV-negative cases, and should be distinguished from granuloma annulare, annular lichen planus, annular psoriasis, scabies, and dermatophytosis. [2][3][4] The main dermoscopic findings of secondary syphilis are Biett's collarette and yellow-orangish hue, while the vascular pattern is indefinite. [5][6][7] Typical Biett's collarette presents as a circular, thin, scaling edge progressing in an outward direction and surrounded by an erythematous halo.…”

“…Secondary syphilis is characterized by a generalized, nonpruritic maculopapular rash with a coppery hue. [1][2][3] However, atypical cutaneous manifestations (nodular, nodulo-ulcerative, annular, pustular, framboesiform, photosensitive eruption) account for 30% of syphilis and have variable histopathological findings and differential diagnoses, 1 which can lead to a diagnostic challenge and therapeutic delay. We describe herein the clinicopathological, dermoscopic, and ultrastructural features of secondary syphilis with annular lesions on the penis.…”

Clinicodermoscopic observation of secondary recurrent syphilis with annular scaly lesions on the penis

“…2 Biett's sign and orangish background are typical dermoscopic features of extragenital syphilis, [5][6][7] but they are missing in penoscrotal annular syphilis. 2,8 In this case, orangish background rather than Biett's sign was present at the inner margin of the raised border in annular plaques. Although orangish background may correspond to dermal hemosiderin deposition, 5 our pathological results showed no hemosiderin deposit and erythrocyte extravasation in the dermis.…”