Solitary Annular Plaque on the Scrotum

Knöpfel, Nicole; Pozo, L.J. del; Díaz, Isaac

doi:10.1097/dad.0000000000000389

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Secondary syphilis presenting as a single lesion is very rarely reported in the literature. Knöpfel et al reported a rare case of secondary syphilis with a single annular lesion on the scrotum, while Wu et al described a similar presentation on the jaw [79,80]. In both cases, histology was necessary to establish a final diagnosis, the differential diagnoses including granuloma annulare, tinea, plaque psoriasis, and sub-acute cutaneous lupus erythematosus [79,80].…”

Section: Discussionmentioning

confidence: 99%

“…Knöpfel et al reported a rare case of secondary syphilis with a single annular lesion on the scrotum, while Wu et al described a similar presentation on the jaw [79,80]. In both cases, histology was necessary to establish a final diagnosis, the differential diagnoses including granuloma annulare, tinea, plaque psoriasis, and sub-acute cutaneous lupus erythematosus [79,80]. A solitary lesion of secondary syphilis may also resemble skin tumors, making the diagnosis even more challenging [81].…”

Section: Discussionmentioning

confidence: 99%

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Syphilis, the Great Imitator—Clinical and Dermoscopic Features of a Rare Presentation of Secondary Syphilis

Cantisani

Rega

Ambrosio

et al. 2023

IJERPH

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Syphilis is characterized by a wide range of variable clinical symptoms; therefore, it is often referred to as “The Great Imitator”. Here, we report the case of a 69-year-old hepatitis-C-positive MSM patient, who was admitted to our clinic due to a solitary firm painless erythematous maculopapular lesion with a central crater-like crust on the upper right thigh that occurred two months prior. The dermoscopy showed an erythematous, copper-colored, oval lesion with diffuse monomorphic dotted and glomerular vessels, central crust, and circular scaling (Biett’s sign). The histological findings ruled out neoplasia and described a plasma cell infiltrate and endothelial swelling. Finally, the combination of the dermoscopic image, histological findings and the additionally acquired knowledge about the sexual history of the patient at the second visit led to the diagnosis, which was then confirmed with serological tests. Dermoscopy may become a supportive tool to facilitate the recognition of secondary syphilis; however, the reporting of these atypical cases is crucial to highlight the many faces of the disease so that clinicians consider syphilis as part of the differential diagnosis of non-specific lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Syphilis, the Great Imitator—Clinical and Dermoscopic Features of a Rare Presentation of Secondary Syphilis

Cantisani

Rega

Ambrosio

et al. 2023

IJERPH

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“…It more often occurs in children and people with dark skin and is primarily seen on the cheeks, often near the angle of the mouth [ 9 , 10 ]. Knöpfel et al reported a rare case of secondary syphilis with a single annular lesion on the scrotum [ 11 ]. Our case had annular lesions limited to palms and soles.…”

Section: Discussionmentioning

confidence: 99%

Annular and Psoriasiform Secondary Syphilis in a Nine-Year-Old Girl Child: A Case Report

Asia¹,

Dhadekar²,

Sadavarte³

2022

Cureus

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Syphilis, a sexually transmitted infection, may pose a challenge to diagnosis if it presents in an unusual form and in rare areas of the body. Non-typical lesions such as annular, maligna, nodular, nodular-ulcerative, corymbiform, leukoderma, pustular, berry-like, and chancriform presentations comprise about 29.6% of the skin manifestations of secondary syphilis. Although typical secondary syphilis is usually not associated with pruritus, 42% of secondary syphilis patients experience itching. A less frequently seen subtype of secondary syphilis is annular secondary syphilis. Its prevalence is approximately 5.7-13.6%. It occurs more commonly in children and people with dark skin. The location is mainly on the cheeks, frequently near the angle of the mouth. In rare cases, it can occur over the penis, feet, and legs. Syphilis in children is a very rare condition as children are seldom sexually active. Infection can occur through either close contact such as kissing, breastfeeding, vertical transmission, or secondary to abuse. We report a rare case of secondary syphilis having psoriasiform as well as annular lesions manifesting mainly on the palms and soles along with generalized lymphadenopathy in a nine-year-old girl. No evidence of hepatosplenomegaly, icterus, or anemia was seen clinically as well as on sonography. Treponema pallidum hemagglutination test was strongly positive. Venereal disease research laboratory test showed a titer of 1:128. Hepatitis B and HIV surface antigen tests were negative. Based on clinical and serological findings, the patient was diagnosed with secondary syphilis, having annular as well as psoriasiform lesions. The patient received tablets of azithromycin 250 mg on the first day. Because of gastritis, the patient was shifted to doxycycline 50 mg twice a day for 14 days. The skin lesions subsided completely after 10 days.

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Annular Secondary Syphilis on the Penis: A Case Report

Zhao

Zheng

et al. 2019

International Journal of Dermatology and Venereology

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Solitary Annular Plaque on the Scrotum

Cited by 5 publications

References 8 publications

Syphilis, the Great Imitator—Clinical and Dermoscopic Features of a Rare Presentation of Secondary Syphilis

Syphilis, the Great Imitator—Clinical and Dermoscopic Features of a Rare Presentation of Secondary Syphilis

Annular and Psoriasiform Secondary Syphilis in a Nine-Year-Old Girl Child: A Case Report

Annular Secondary Syphilis on the Penis: A Case Report

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