Solitary bronchial neuroma associated with asthma: chronic irritation pathogenesis?

A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo

“…32 Because 306O i10 transfects the major liver cell types with equal potency, its potential therapeutic applications extend to liver diseases that affect multiple cell types, such as hepatitis, fatty liver disease, cancer, and inherited diseases. [33][34][35][36] For example, an mRNA therapy for hepatocellular carcinoma could target malignant hepatocytes, endothelial cells, and Kupffer cells simultaneously.…”

Clinicopathological Characteristics and Pathogenesis of Granular Cell Tumours of the Airways

“…Although a causal agent for GCTs has not been identified, the association with tobacco use is clear, 2 as confirmed in our series. In terms of pathogenesis, we postulate that tobacco smoke could generate respiratory neural proliferation as a consequence of peripheral nerve lesions, as it has been postulated in relation to chronic irritation by asthma 3 . It is known that peripheral neuropathy is produced in chronic obstructive pulmonary disease and that it is characteristically caused by long-term exposure to cigarette smoke 4 .…”

“…In terms of pathogenesis, we postulate that tobacco smoke could generate respiratory neural proliferation as a consequence of peripheral nerve lesions, as it has been postulated in relation to chronic irritation by asthma. 3 It is known that peripheral neuropathy is produced in chronic obstructive pulmonary disease and that it is characteristically caused by long-term exposure to cigarette smoke. 4 Furthermore, experimental results suggest that chronic nicotine increases hypersensitivity after peripheral nerve injury.…”