Solitary Cutaneous Epithelioid Angiomatous Nodule Associated with Unilateral Capillary Malformation

Chokoeva, Anastasiya Atanasova; Maximov, Georgi Konstantinov; Wollina, Uwe; Patterson, James W.; Tchernev, Georgi

doi:10.2340/00015555-2487

Cited by 5 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,7 Instead, most of the CEAN cases in the literature seem to be similar to conventional subtype epithelioid hemangioma or classic cutaneous ALHE, as seen in Cases 1 and 2 in this study. 5,10,13,15,18,24 Moreover, CEAN cases combined with multiple pyogenic granulomas 19 or capillary malformations 11,20 have been reported. Therefore, the CEAN cases in literature form a heterogeneous group, and most of them may actually be conventional subtype epithelioid hemangioma or classic cutaneous ALHE.…”

Section: Discussionmentioning

confidence: 99%

“…We performed a thorough search regarding CEAN using PubMed search engines and found 66 CEAN cases in 28 existing studies in English between 2004 and 2021 1–28 . These CEAN tumors were observed in patients (38 males and 28 females) aged 14–84 years (average, 42.0 years).…”

Section: Discussionmentioning

confidence: 99%

“…A cutaneous epithelioid angiomatous nodule (CEAN) is a rare cutaneous vascular entity first described in 2004 by Brenn and Fletcher 1 . Since then, 66 cases have been reported in 28 papers 1–28 . Owing to the histopathological features of the epithelioid endothelial cells, this benign tumor can be easily confused with other benign, borderline, or malignant vascular tumors, including bacillary angiomatosis, Kaposi sarcoma, epithelioid hemangioendothelioma, and epithelioid angiosarcoma.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions

et al. 2022

View full text Add to dashboard Cite

Background The status of cutaneous epithelioid angiomatous nodule (CEAN) as a distinct entity remains controversial. This study investigated the relationship between CEAN and epithelioid hemangioma/angiolymphoid hyperplasia with eosinophilia (ALHE). Methods Data of seven lesions with CEAN features from four cases (Cases 1–4: 61‐year‐old, 76‐year‐old, 53‐year‐old, and 21‐year‐old men, respectively) were investigated. Results Cases 1 and 2 showed multiple lesions in the head and neck region, but Cases 3 and 4 showed solitary lesions on the back and scalp, respectively. Moreover, the histopathologic findings of the lesions of Cases 1 and 2 were consistent with those of conventional epithelioid hemangioma or classic cutaneous ALHE. Diffuse immunoexpression of FOSB was observed in Cases 1 and 2, but FOSB split signals were absent in break‐apart fluorescence in situ hybridization (FISH). In contrast, the histopathologic findings of the lesions of Cases 3 and 4 were consistent with those of cellular‐type epithelioid hemangiomas. Diffuse immunoreactivity for c‐FOS was observed in Cases 3 and 4, and split signals of FOS were present in break‐apart FISH in Case 3. Conclusions This study showed that the seven tumors with CEAN features could be reclassified under the epithelioid hemangioma/ALHE group, although the small sample size is a limitation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Cutaneous epithelioid angiomatous nodule is a rare, benign, reactive vascular proliferation that was first described by Brenn and Fletcher in 2004 [ 2 ]. Since then, there have been in excess of 20 case reports and or small series in the English literature [ 2 – 22 ]. Clinically, these lesions present as a rapidly growing small, solitary nodules or papules, however; multiple lesions have also been reported [ 2 – 4 , 8 , 12 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression

Chetty¹,

Kamil²,

Wang³

et al. 2018

Diagn Pathol

View full text Add to dashboard Cite

BackgroundCutaneous epithelioid angiomatous nodule (CEAN) is a very rare and relatively recently recognized vascular proliferation characterized usually by minimal cytological atypia and accompanying mitotic activity. As such, CEAN represents an important diagnostic pitfall, which could lead to significant misdiagnosis and unnecessary treatment.MethodsThe clinicopathologic findings of 5 cases of CEAN were reviewed including a unique case with typical findings but also moderate cytologic atypia and brisk mitotic activity in a patient on immunosuppression.ResultsThe cases were in 3 women and 2 men ranging in age from 18 to 61 years with lesions in the neck (2 cases), upper arm, back and shoulder. In 4 of the cases, the patients did not have any relevant potentially contributory clinical history, and in 1 case the patient was on immunosuppressive treatment. All 5 cases were superficially located within the dermis, well-circumscribed and similarly composed of epithelioid cells displaying minimal (in 4 cases) and moderate (1 case) atypia. The mitotic count ranged from 1 to 3 per 10 high power fields (HPF) in 4 cases and up to 9 per 10 HPF in the immunosuppressed patient. Atypical mitoses were not encountered in any of the cases. Two lesions that were incompletely excised recurred, but none of the patients showed distant metastases.ConclusionWhile cytologically alarming, CEAN has a characteristic microscopic appearance and if completely excised follows an indolent course.

show abstract

“…, und in sehr seltenen Fällen entstehen Läsionen in fehlgebildeten Kapillaren[ 9,10 ] .Histologischsind epitheloide angiomatöse Knoten charakterisiert durch eine feste, schichtartige, deutlich abgegrenzte und nicht verkapselte unilobuläre Proliferation bestehend aus großen epitheloiden Endothelzellen mit fokaler Bildung verzweigter vaskulärer Kanäle in der oberen Dermis. Häufi ge Befunde sind eine Hyperplasie der Epdermis und kragenförmige Reteleisten.…”

unclassified

Erythematous non‐ulcerated nodule of the scapular region

Varas‐Meis

Espasandín‐Arias

Rodríguez-Prieto

2018

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Solitary Cutaneous Epithelioid Angiomatous Nodule Associated with Unilateral Capillary Malformation

Cited by 5 publications

References 8 publications

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions

Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression

Erythematous non‐ulcerated nodule of the scapular region

Contact Info

Product

Resources

About