Solitary eccrine syringofibroadenoma - Case Report

Abstract

Eccrine syringofibroadenoma is a rare benign adnexal neoplasm derived from cells of the acrosyringium of eccrine sweat glands. ESFA usually manifests as a solitary nodule on the extremities of elderly patients, but it may also present as papules, nodules or plaques. Its clinical appearance is nonspecific and malignant neoplasms should beconsidered in the differential diagnosis. However, histopathological findings are typical. The main treatment is surgical excision. In order to illustrate a typical presentation of the tumor, we report a case of solitary eccrine syringofibroadenoma, including the surgical treatment used and its result.

Eccrine Syringofibroadenoma Associated with Bowen's Disease: A Case Report and Review of the Literature

“…Although glandular proliferation is rarely observed in SCC, glandular components are typically negative for CEA, and prominent keratinization, keratin pearl and cytologic atypia are typically present in SCC in contrast to ESFA 18 . The treatment of choice is complete surgical excision since it is impossible to exclude malignant transformation of ESFA 1,2 . When complete excision is difficult due to large involvement area or poor patient condition for surgery, close observation may be an alternative to early excision 2 .…”

Reactive Eccrine Syringofibroadenoma Associated with Neuropathy, Venous Stasis, and Diabetic Foot Ulcer

“…Eccrine syringofibroadenoma (ESFA), first described by Mascaro [ 1 ] in 1963, is a rare benign adnexal neoplasm considered to originate from the excretory portion of eccrine sweat glands [ 2 ]. It typically presents in elderly patients between the 7th and 8th decade of life.…”

“…The distribution of the lesions is most often on the extremities. Less commonly affected parts include the face, torso, buttock, nail, and peristomal skin [ 2 , 3 ].…”

“…ESFA is categorized into 5 subtypes according to its clinical presentation: (1) solitary ESFA, a solitary verrucous nodule in elderly adults; (2) multiple ESFA associated with Clouston syndrome and Schöpf-Schulz-Passarge syndrome; (3) multiple ESFA without associated cutaneous findings, also referred to as syringofibroadenomatosis; (4) nonfamilial unilateral linear ESFA (nevoid ESFA), and (5) reactive ESFA associated with inflammatory or neoplastic dermatoses (e.g., erosive lichen planus, bullous pemphigoid, epidermolysis bullosa, primary cutaneous amyloidosis, burn scar, venous stasis, chronic diabetic foot ulcer, neuropathy, nevus sebaceous, and squamous cell carcinoma) [ 2 , 4 5 6 7 8 9 10 11 ].…”

“…In unresectable cases, monitoring and generous sampling to rule out malignant transformation are recommended [ 3 , 9 ]. Other treatment options include cryotherapy, curettage, electrodessication, ablative laser therapy, photodynamic therapy, radiotherapy, 5-fluorouracil, imiquimod, and topical and systemic retinoids with variable outcomes [ 2 , 8 , 15 ].…”