Solitary fibrous tumor in the liver: case report and literature review

Yugawa, Kyohei; Yoshizumi, Tomoharu; Mano, Yohei; Kurihara, Toshio; Yoshiya, Shohei; Takeishi, Kazuki; Itoh, Shinji; Harada, Noboru; Ikegami, Toru; Soejima, Yuji; Kohashi, Kenichi; Oda, Yoshinao; Mori, Masaki

doi:10.1186/s40792-019-0625-6

Cited by 24 publications

(9 citation statements)

References 18 publications

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“…The staining of CD34 is useful to distinguish SFT from other spindle cell neoplasms. However, a small percentage (5%-10%) of classical SFT is immunohistochemically negative for CD34[ 23 ]. Recent studies confirm that the NAB2-STAT6 fusion gene has excellent sensitivity and specificity for the diagnosis of SFT than other conventional immunohistochemical markers[ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the liver: A case report and review of the literature

Xie¹,

Zhu²,

Yun³

et al. 2022

WJCC

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Solitary fibrous tumor (SFT) is a rare mesenchymal tumor. Given its origin, it can appear in almost any location. In the literature, only 50 cases of SFT in the liver parenchyma have been reported. Despite its rarity, this entity should be included in the differential diagnosis of liver masses. We report the first case with imaging data from five years prior to diagnosis, which was treated by right portal embolization and arterial tumor embolization, and subsequent liver resection. We also present an exhaustive review of the cases described to date.

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Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the liver: A case report and review of the literature

Xie¹,

Zhu²,

Yun³

et al. 2022

WJCC

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“…SFTs are mesenchymal neoplasms previously expressed as hemangiopericytoma that classically origin from the pleura, but they have been reported in other extra-thoracic sites (1,2). Liver is an extremely rare origin of SFTs with only 84 cases reported in the English literature since 1958 (3). These tumors are more common in females.…”

Section: Discussionmentioning

confidence: 99%

“…The follow-up often shows benign local recurrences. Nonetheless, there are few reports of metastatic spread to other areas of the body (3,4) suggesting long-term follow up of these patients.…”

Section: Radiologic Findings Cannot Differentiate Betweenmentioning

confidence: 99%

“…Nonetheless, in later studies, it appeared that these tumors can also grow in other areas such as meninges, spinal cord, peritoneum, retroperitoneum, adrenal gland, thyroid gland, pelvis, soft tissue, orbit, and mediastinum (2). Liver has been rarely reported as the location of solitary fibrous tumor and there are less than 100 cases in the literature addressing it (3).…”

Section: Introductionmentioning

confidence: 99%

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Radiologic and Pathologic Findings of a Huge Solitary Fibrous Tumor of the Liver with Malignant Transformation: A Case Report

Yazdi¹,

Dashti²,

Safaei³

et al. 2020

Iran J Radiol

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Solitary fibrous tumors (SFTs) are mesenchymal tumors that mostly occur in the pleural cavity. Extra-thoracic location is rare and hepatic origin is extremely rare. Most lesions are benign, 10% -15% show aggressive behavior and few metastasizing SFTs have been reported. Imaging features of solitary fibrous tumors of the liver (SFTLs) are nonspecific and definite diagnosis usually needs histopathological and immunohistochemistry evaluation. We report ultrasound, CT and MRI features of such a rare malignant SFTL in a 47-year-old man who came with vague abdominal symptoms in detail along with reviewing literature considering imaging features which is valuable for radiologists. The lesion seen as a huge dominantly cystic lesion on ultrasound was initially misinterpreted as hydatid. On CT scan it was seen as a large encapsulated mass with arterial hyper-enhancement and delayed contrast retention and multiple cystic spaces. On MRI, solid components showed iso-intensity to adjacent liver on T1 and T2 images, small areas of restriction on diffusion weighted imaging (DWI) and few hemorrhagic cystic components beside enhancement pattern and multiple large cystic components similar to CT scan. Our patient was admitted for resection of huge hepatic mass and experienced an episode of altered mental status due to hypoglycemia during hospital admission, which is a rare finding in SFTL. The patient underwent right hepatectomy and solitary fibrous tumor was confirmed on pathologic examination of the resected tumor. Hypoglycemic episodes were resolved and the patient was asymptomatic in 28 months follow-up.

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“…SFT is considered a benign tumor with the potential for malignant transformation but the classification of this neoplasm is not yet clear in literature[4,10]. SFT of the liver (SFTL) is particularly rare, therefore the classification as a benign or malignant tumor remains controversial[11]. SFTL was reported for the first time in an article published in 1959 by Nevius and Friedman where three SFT in different localizations were described, one of them was a liver SFT and was clinically presented with hypoglycaemia[12].…”

Section: Discussionmentioning

confidence: 99%

Doege-Potter syndrome by malignant solitary fibrous tumor of the liver: A case report and review of literature

Delvecchio¹,

Duda²,

Conticchio³

et al. 2019

WJGs

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BACKGROUND Solitary fibrous tumor of the liver (SFTL) is a rare occurrence with a low number of cases reported in literature. SFTL is usually benign but, 10%-20% cases are reported to be malignant with a tendency to metastasize. The majority of malignant SFTL cases are associated with a paraneoplastic hypoglycaemia defined as Doege-Potter syndrome. Surgery is the best therapeutic treatment, however, long- life follow-up is recommended. CASE SUMMARY A 74-year-old man, was admitted to the emergency department after a syncopal episode with detection of hypoglycaemia resistant to medical treatment. The computed tomography revealed a solid mass measuring 15 cm of the left liver. An open left hepatectomy was performed with complete resection of tumor. Histopathological analyses confirmed a malignant SFTL. CONCLUSION Large series with long-term follow-up have not been published neither have clinical trials been undertaken. Consequently, the methodical long-term follow-up of surgically treated SFTLs is strongly recommended.

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Solitary fibrous tumor in the liver: case report and literature review

Cited by 24 publications

References 18 publications

Solitary fibrous tumor of the liver: A case report and review of the literature

Solitary fibrous tumor of the liver: A case report and review of the literature

Radiologic and Pathologic Findings of a Huge Solitary Fibrous Tumor of the Liver with Malignant Transformation: A Case Report

Doege-Potter syndrome by malignant solitary fibrous tumor of the liver: A case report and review of literature

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