Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

Abstract

Solitary fibrous tumor (SFT) is a rare and still controversial entity. This type of tumor first appeared in the literature as a pleural lesion, but, over the last decades, it has been reported in many extrathoracic sites. As a tumor of the adrenal gland, SFT is still rare and very uncommon, thus extensive research among the English language literature has been performed. We present here a case report of an adrenal SFT which is compared to 11 other known cases. Our case report is from a patient with SFT on the left adrenal gland, followed by mild symptoms of abdominal discomfort and hypertension. Physical examination, laboratory, and radiological tests were performed. The patient underwent surgery and the material was sent for histopathologic analysis for a definite diagnosis. Regular follow up appointments were performed over the course of two years. No recurrence of the tumor has been detected. We explain the symptoms, diagnosis, treatment, and additionally we describe the results and implications of the findings reported in the literature. Correct diagnosis is mandatory for optimal management of solitary fibrous tumor patients.

Adrenal Solitary Fibrous Tumor: A Case Report

“…It is important to note that while STAT6 immunohistochemistry is a sensitive surrogate for detecting STAT6 fusion, it can also exhibit positivity in other entities, such as dedifferentiated liposarcoma, a more commonly occurring tumor in the retroperitoneum. Therefore, the inclusion of MDM2 amplification analysis is imperative in this context to differentiate from dedifferentiated liposarcoma [ 3 , 4 , 11 ].…”

“…Solitary fibrous adrenal tumor (SFAT) is an extremely rare mesenchymal neoplasm, with only a few cases reported in the literature. Ambardjieva et al conducted a review of published data up to 2021 and identified 12 reported cases of SFAT [ 3 ]. The patients' ages ranged from 23 to 77 years, and SFAT was often discovered incidentally during imaging intended for other reasons, without symptoms or lumbar pain.…”