Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study

Yuri, Takashi; Kanematsu, Sayaka; Lei, Yen-Chang; Kuwata, Maki; Oishi, Masaharu; Tsubura, Airo

doi:10.1007/s00795-009-0451-1

Cited by 4 publications

(15 citation statements)

References 24 publications

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“…The diameter of the tumor was 2 × 3 cm, and immunoreactive IGF-II was detected by histology; however, hypoglycemia was not seen in this patient an observation that suggests only when the tumor increases in size will the levels of IGF-II increase at least to some degree, following which, the onset of hypoglycemia will be seen. [42] …”

Section: Diagnostic Methods/markersmentioning

confidence: 99%

Doege–Potter syndrome

Han¹,

Zhang²,

Xing-bin³

et al. 2017

Medicine

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Rationale:We reviewed 76 published cases of Doege–Potter syndrome, and non-islet cell tumor hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT) between 1989 and 2016, to study disease pathogenesis, diagnosis, and treatment of this rare paraneoplastic disease. Further, we report 1 new case of a patient presenting with Doege–Potter syndrome.Patients concerns:The tumors originated from the pleural cavity, lung, pelvis, liver, retroperitoneum, kidney, mediastinal, the sella, uterus, bladder, intestine, mandibular, and the thigh. The most common location was the pleural cavity (left 12 cases and right 28 cases). Moreover, 28/71 (39.4%) were benign and 43/71 (60.6%) were malignant. SFTs with NICTH were more likely to be malignant and present at a higher rate than previously published (5%–10.4%). The malignancy rate of extrathoracic SFTs was higher than that of thoracic SFTs, 20 (66.7%) as compared with 23 (56.1%). Age of onset varied from 24 to 85 years (mean 59 years), with 47 males and 28 females, and gender unavailable for 1 case. When comparing clinical characteristics of patients with benign as compared malignant tumors, no significant differences in the age of onset, gender, or size of tumor were seen. Among 15/19 cases, the insulin-like growth factor II (IGF-II)/IGF-I ration was >10.0. Complete tumor resection remained the only definitive treatment.Outcomes and lessens:Glucocorticoids dose-dependently reduce the frequency and severity of hypoglycemic episodes. Low doses of prednisone were ineffective at relieving hypoglycemia. The effect of neoadjuvant treatment, consisting of chemoradiation, and consecutive selective embolization of vessels feeding the tumor were not identified.

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Section: Diagnostic Methods/markersmentioning

confidence: 99%

Doege–Potter syndrome

Han¹,

Zhang²,

Xing-bin³

et al. 2017

Medicine

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“…For definitive treatment, total resection of the tumor is the gold standard, 20 - 38 although in some circumstances the mass is too big and has great vascularity leading to intra-operative bleeding as one of the main complications. In these situations, it is best to evaluate preoperatively the tumors vascularity using an angiogram and decide whether embolization to reduce vascularity is the best option, prior to resection.…”

Section: Discussionmentioning

confidence: 99%

“…21,22 On binding to insulin receptors, it facilitates glucose transport to the muscles and inhibits gluconeogenesis in the liver and lipolysis in the adipose tissues, leading to the development of hypoglycemia in patients with tumors that secrete large amounts of high-molecularweight IGF-2. [23][24][25] Definitive diagnosis of DPS is established by measuring serum GH, IGF-1, and IGFBP-3 levels, which are usually decreased, along with IGF-2 levels, which can vary, and highmolecular-weight IGF-2 levels, which are increased. 20 The IGF-2/IGF-1 ratio can be calculated, which tends to be <10.…”

Section: Introductionmentioning

confidence: 99%

Doege–Potter Syndrome and Hypoglycemia associated with Solitary Fibrous Tumor of the Pleura: Two Case Reports

Fernández-Trujillo

Bolaños

Álvarez

et al. 2020

Clin Med Insights Circ Respir Pulm Med

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Solitary fibrous tumors of the pleura (SFTP) are rare mesenchymal neoplasms that originate from mesenchymal growth in the pleura, tend to be single tumors, usually have an indolent course and show nonspecific symptoms. SFTP can be often diagnosed from an incidental finding of a single mass in the thorax and should be confirmed by biopsy and immunohistochemistry. A minority of cases may present Doege–Potter syndrome (DPS, episodes of refractory hypoglycemia) associated with production of insulin-like growth factor 2 (IGF-2). Both SFTP and DPS are rare occurrences with less than 2000 cases reported worldwide. The curative treatment is tumor resection. Two cases of patients with DPS caused by SFTP are presented below.

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“…Hemangiopericytoma, first described by Stout and Murray in 1942, identified a group of vascular tumors with probable origin in the pericytes of Zimmerman [5]. However, all of these tumors have a common mesenchymal origin, with similar histological and immunohistochemical characteristics [1,6].…”

Section: Discussionmentioning

confidence: 99%

“…Solitary Fibrous Tumors (SFT), represent a group of rare tumors of mesenchymal origin with unique morphological and immunohistochemical features, usually identified in the pleura, although it can also be found in other locations including soft tissues [1][2][3][4]. Extrapleural SFTs represent 0.6% of all soft tissue tumors.…”

Section: Introductionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Abdominal Wall

Oliva¹,

Velez²,

Bento³

et al. 2014

J Clin Case Rep

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Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually arise within the pleura. Its origin in abdominal wall is extremely rare, with only 15 cases described in the English literature.We report the case of a 55-year-old woman presented with a mass located at the left lower quadrant of the abdominal wall. Microscopic studies revealed histologic and immunohistochemical features consistent with a SFT. Eighteen months after surgical excision of the mass followed by adjuvant radiotherapy, the patient is alive and disease-free. The authors discuss the clinicopathological features of SFTs, differential diagnosis and treatment options.

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Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study

Cited by 4 publications

References 24 publications

Doege–Potter syndrome

Doege–Potter syndrome

Doege–Potter Syndrome and Hypoglycemia associated with Solitary Fibrous Tumor of the Pleura: Two Case Reports

Solitary Fibrous Tumor of the Abdominal Wall

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