Solitary Fibrous Tumor of the Orbit

O’Donovan, David; Bilbao, Juan M.; Fazl, Mahmood; Antonyshyn, Oleh

doi:10.1097/00001665-200209000-00009

Cited by 32 publications

(28 citation statements)

References 18 publications

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“…Several studies point to the fact that no conclusion of the clinical course can be drawn from the histological findings [39]. There are histologically malignant tumors having both an aggressive as well as benign outcome; on the other hand, histologically benign features are no guarantee of a good outcome.…”

Section: Discussionmentioning

confidence: 99%

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Solitary fibrous tumor of the orbit?two cases and a review of the literature

Romer

Bode

Schuknecht

et al. 2004

Eur Arch Otorhinolaryngol

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Solitary fibrous tumors of the orbit (SFT) are mesenchymal lesions that can develop either as malignant or benign neoplasias. We describe the histological features leading to the diagnosis in two females and review the current literature. Diagnosis of SFT only can be performed by histological examination, since clinical signs and radiological features are not specific enough. Even a malignant or benign course cannot be predicted, since clinical and radiological features do not correlate with histological signs of malignancy and vice versa. Radical resection is the treatment of choice, since no other treatment option has been proven to be efficient. Abstract Solitary fibrous tumors of the orbit (SFT) are mesenchymal lesions that can develop either as malignant or benign neoplasias. We describe the histological features leading to the diagnosis in two females and review the current literature. Diagnosis of SFT only can be performed by histological examination, since clinical signs and radiological features are not specific enough. Even a malignant or benign course cannot be predicted, since clinical and radiological features do not correlate with histological signs of malignancy and vice versa. Radical resection is the treatment of choice, since no other treatment option has been proven to be efficient.

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Section: Discussionmentioning

confidence: 99%

“…To our knowledge, there are up to 50 SFTs of the orbit described [1,4,5,6,8,13,15,16,17,18,19,20,21,26,27,28,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46]. The aim of the present study is to present two cases and to review the current literature.…”

Section: Introductionmentioning

confidence: 95%

Solitary fibrous tumor of the orbit?two cases and a review of the literature

Romer

Bode

Schuknecht

et al. 2004

Eur Arch Otorhinolaryngol

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“…Solitary fibrous tumor (SFT) is a rare spindle-cell tumor of mesenchymal origin that arises most often in the pleura, but may also occur at other organs, including lung, mediastinum, pericardium, peritoneum, retroperitoneal space, pelvis, adrenal gland, kidney, liver, periosteum, salivary gland, thyroid gland, lacrimal gland, breast, nasopharynx, orbit, urogenital system, skin, meninges and spinal cord 3,10,11,13,14,19,21,24,27,33) . Since the first report of orbital SFT by Westra et al 34) in 1994, fewer than 60 cases of orbital SFTs have been reported to date.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, with the development of immunohistochemical method, the number of reported cases have been increasing 9) . One of the most common symptoms is unilateral painless proptosis, which can be accompanied by visual disturbance, palpable orbital mass, ocular mobility disturbance, hyperglobus or blepharoptosis from the secondary mass effect in the orbit 24) . As a general rule, orbital SFT shows an indolent and nonaggressive clinical course.…”

Section: Introductionmentioning

confidence: 99%

Orbital Solitary Fibrous Tumor : A Case Report and Diagnostic Clues

Park

Kim

et al. 2009

J Korean Neurosurg Soc

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J Korean Neurosurg Soc 46 : [77][78][79][80] 2009 Orbital solitary fibrous tumor (SFT) is a rare tumor originating from the mesenchyme. We describe the clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT. The patient was a 46-year-old female who presented with progressive proptosis advanced for 20 months. On ophthalmological examination, no visual impairment was detected, but left eye was found to be obviously protruded on exophthalmometry. Orbital magnetic resonance imaging showed a 2.5 × 2 × 2 cm, intensely enhanced mass in the left orbit, which compressed the eyeball forward and the optic nerve downward. The patient underwent frontal craniotomy with superior orbitotomy and gross total resection was performed for the tumor. The histopathological diagnosis including immunohistochemistry was a SFT. After the surgery, proptosis was markedly relieved without visual impairment. Although orbital SFT is extremely rare, it should be considered in the differential diagnosis of orbital tumors. Clinical presentations such as painless proptosis and CD34 immunoreactivity play a significant role in differentiating orbital SFT from other spindle-cell neoplasms of the orbit.

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“…The biopsy may show large areas of the tumour containing storiform formations, sarcoma-like areas, fascicular formations, neural type palisades, and hemangiopericytoma-like patterns [6]. Differential diagnosis based on histopathological features includes meningioma, fibrous histiocytoma, schwannoma and hemangiopericytoma.…”

Section: Resultsmentioning

confidence: 99%

Solitary Fibrous Tumour of Lacrimal Gland: A Rare Entity

Narang

et al. 2015

JCDR

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A 52-year-old male presented to the ophthalmology outpatient department with complaints of swelling in the left supero-lateral aspect of the orbit (lacrimal gland region) for past two years. Patient gave history of gradual increase in size of the lesion. On examination, the swelling was apparently soft and non tender. He ruled out any history of trauma at this site. No associated ocular complaints were present. Routine investigations like Complete blood counts, Liver function tests, Renal function tests, Viral markers (HIV, HbsAg and HCV) were unremarkable. Magnetic resonance imaging (MRI) and FNAC were advised with clinical possibility of Lipoma. MRI revealed an extra corporal mass on supero lateral aspect of left orbit possibly lacrimal in origin [Table/ Fig-1]. FNAC smears were scantily cellular and exhibited spindle shaped cells with bland chromatin and inconspicous nucleoli against a haemorrhagic background. Scant cellularity hampered the diagnosis and only a suggestion of neoplastic nature of the lesion was offered. Wide local excision of the lesion was planned and tissue was sent for histopathology.Histopathological examination revealed partly encapsulated cellular tumour arising from the lacrimal gland. The tumour cells were arranged in patternless sheets and fascicles with focal storiform pattern. The tumour cells had spindle shaped nuclei with moderate Pathology SectionSolitary Fibrous Tumour of Lacrimal Gland:A Rare Entity aBstRaCt Solitary fibrous tumour (SFT) is a rare spindle cell tumour of mesenchymal origin most commonly encountered in pleura. It can affect the orbital region but SFT of lacrimal gland is rare. We hereby report of a SFT of lacrimal gland in a 50-year-old male presenting with slow growing swelling in left superolateral orbital region. The preliminary fine needle aspiration cytology (FNAC) could not reveal any definite diagnosis. Excision biopsy and immunohistochemistry (IHC) confirmed the diagnosis. Therefore, clinician and pathologist should be aware of this entity and biopsy along with IHC is required to rule out other entities which can mimic it clinically and histopathologically.Vikram NaraNg 1 , Nagi aNitaraj rajeNdra SiNgh 2 , gurkirat SiNgh Bajwa 3 , NeeNa Sood 4 amount of ill defined eosinophilic cytoplasm and an occasional mitotic figure. Histomorphology was suggestive of benign spindle cell tumour. IHC was done to rule out the possibility of schwannoma/ hemangiopericytoma. On IHC the tumour cells were positive for CD34, Vimentin and negative for SMA and S100 on IHC [Table/ Fig2a-d]. The MIB1 labelling index was less than 1%. Hence, the final diagnosis of SFT of lacrimal gland was made. The patient is now on follow up and shows no evidence of local recurrence. DisCussionSFT is a rare tumour of adults that originally was believed to be derived from mesothelium. However, the subsequent identification of this tumour in sites not usually associated with serosal surfaces, including the thyroid and parotid glands, nasal cavity, and paranasal sinuses, supports a mesenchymal origi...

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Solitary Fibrous Tumor of the Orbit

Cited by 32 publications

References 18 publications

Solitary fibrous tumor of the orbit?two cases and a review of the literature

Solitary fibrous tumor of the orbit?two cases and a review of the literature

Orbital Solitary Fibrous Tumor : A Case Report and Diagnostic Clues

Solitary Fibrous Tumour of Lacrimal Gland: A Rare Entity

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