Solitary fibrous tumor of the thyroid: Cytopathologic findings and differential diagnosis

Abstract

Solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm that arises primarily from the pleura. Extrapleural occurrences are rare. To our knowledge, there is no published account of this entity in the thyroid in the cytopathology literature. We report the case of a 61-yr-old man who was evaluated at The Johns Hopkins Hospital for a slow-growing thyroid mass that was present for 2 yr despite thyroid hormone suppression. Thyroid-stimulating hormone (TSH) was within normal limits. The patient underwent ultrasound-guided fine-needle aspiration (FNA), which showed predominantly discohesive slender spindle-shaped cells and fragments of collagenized stromal tissue. After the FNA diagnosis of "thyroid neoplasm" was made, the patient underwent a near-total thyroidectomy, which revealed a SFT. Differential diagnosis of spindle cell lesions in thyroid is also presented.

Solitary Fibrous Tumour of Thyroid: Report of Two Cases with Immunohistochemical Features and Literature Review

“…A review of the literature regarding primary thyroid SFT, showed only 19 cases being reported to date ( [7][8][9][10][11][12][13][14][15][16][17] and Table 3). The morphological and immunohistochemical features of SFT of thyroid, including our cases, are identical to pleural-based solitary fibrous tumours.…”

“…With regard to the thyroid gland, only 19 cases have been reported to date [7][8][9][10][11][12][13][14][15][16][17].…”

Solitary fibrous tumor in the thigh: review of the literature

“…Despite they are seldom located in extrapleural soft tissue this tumor has been reported in a variety of extraserosal sites (Ramdial and Madaree 2001). By reviewing the literature following locations are described: lumbar extradural (Donnellan et al 2000), intrameningeal (Nawashiro et al 2000;Kawamura et al 2004), in cervical spine (Obara et al 2003;Bohinski et al 2004), in the deep soft tissue of the neck (Goh et al 2002;Bachmeyer et al 2004), in orbital space (Ahn et al 2001;O'Donovan et al 2002;Schellini et al 2003), in pelvic space (Ishikawa et al 2004), retroperitoneal (Nagasako et al 2004), vaginal (Akiyama et al 2000), in the thyroid gland (Parwani et al 2003;Babouk 2004), in mammary gland (Falconieri et al 2004), in prostate (Ishii et al 2004), in nasal mucosa (Munks 2003), in the liver (Neeff et al 2004), in renal pelvis (Yazaki et al 2001;Magro et al 2002), and in extremities (Akisue et al 2003). All of these tumors are diagnosed and categorized by histology and immunohistochemical patterns.…”

Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature

“…Only two reports showed a diagnosis of spindle-cell neoplasm using cytology combined with immunocytochemistry, but a definitive confirmation of SFT-T was not possible using this method alone (5,13). The FNAB of the present patient showed a benign lesion, most likely granulomatous thyroiditis.…”

“…Albeit it has been originally recognized as a localized form of mesothelioma (2), some studies have reported extrapleural sites in the body (3,4), such as thyroid, salivary glands, tongue, respiratory tract, orbit, liver, meninges and retroperitoneum (3,5). They are very rare in the thyroid gland, with only 26 cases described after the original report in 1993 (6,7).…”