Solitary fibrous tumor of the breast: A rare neoplasm

Brenes, Juana María; Moreno, A.; Merchan, M.J.; Montes, Myriam; Ciudad, M.J.; Riola, Cristina; Olivares, María Eugenia; Cortes, José A.; Cuadrado, M A; Román, José Marı́a

doi:10.1111/tbj.12925

Cited by 6 publications

(6 citation statements)

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“…Although breast SFT was accidentally detected by routine mammography, most breast SFT cases, including this one, were diagnosed upon the presence of palpable masses of varying sizes (0.6 cm-10 cm with a mean diameter of 3.31 cm and median diameter of 3 cm) and accompanying pain in individual cases. 11,21,23 According to previous reports, 12 cases were in the left breast and 13 cases were in the right breast, suggesting no significant laterality. The age of patients ranged from 38 to 88 years (mean age = 61.4; median = 62).…”

Section: Discussionmentioning

confidence: 89%

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A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

et al. 2022

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Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm which may arise in a wide range of anatomic location and can occur across all ages. Fat-forming SFT is a rare morphological variant of SFT. Primary breast fat-forming SFT is exquisitely rare. Here, we report a case in a 51-year-old Chinese woman with a palpable painless mass in the left breast. A color Doppler ultrasound scan examination demonstrated a 3.4-cm oval, well-circumscribed, hypoechoic solid mass with several peripheral and internal color flow signals. Magnetic resonance imaging (MRI) showed a focal lobulated solid nodular lesion displaying geographical enhancement but no architectural distortion. Subsequently, she underwent a left breast lumpectomy. In histopathologic examination, there was a well-circumscribed, cellular spindle cell tumor consisting of short fascicles of bland, fusiform, ovoid to spindle cells disposed in a patternless architecture around branching vascular spaces within a fibrous stroma with wispy collagen. Cells revealed mild nuclear atypia. Mitotic figures were up to 4/10 high-power fields (HPFs) in the hot spot. Mature adipocytes intermixed with spindle cells were also observed. The tumor cells were diffusely positive for CD34 and STAT6. Some S100-expressing adipocytes co-expressed STAT6. Next-generation sequencing (NGS) revealed the presence of the NAB2exon6::STAT6exon2 fusion. The histological, immunohistochemical (IHC) and molecular examinations confirmed the diagnosis of fat-forming SFT. Post-excision, the patient showed no signs of tumor recurrence or metastasis in a 7-month follow-up. Here, we describe a rare case of a fat-forming SFT involving the breast and highlight the comprehensive pathological evaluation and necessary ancillary testing.

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Section: Discussionmentioning

confidence: 89%

“…1 To date, only 33 cases of breast SFT have been reported in the previous English literature, of which only 1 case was fat-forming SFT (summarized in Table 1). 2–28 Here, we report a case of breast fat-forming SFT with focal atypical features. We also reviewed the clinical features and diagnostic hallmarks of breast fat-forming SFT.…”

Section: Introductionmentioning

confidence: 91%

A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

et al. 2022

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“…Long-term post-treatment monitoring should be considered when detecting late recurrences. Tumor protein p53 (TP53) IHC expression is associated with recurrence and metastasis [ 1 , 2 , 16 ]. Tariq et al reported the survival rate for extra-pleural SFT localization as follows: a 5-year survival rate of 89% and a 10-year survival rate of 73% [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Following our review of the literature, we found that the follow-up for breast SFT ranged from 5 to 132 months, with a local recurrence that was reported in only two cases, one treated by re-excision and the other by mastectomy. No disease-related deaths were reported [ 2 , 7 , 9 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Incidental finding of solitary fibrous tumor of male breast: case report and review of literature

El-Helou

Zaiter²,

Hoang³

et al. 2023

Rom J Morphol Embryol

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Solitary fibrous tumor (SFT) of the breast is a rare mesenchymal tumor composed of spindle-shaped tumor cells with collagen and large blood vessels in the shape of a "staghorn". It is discovered anywhere in the human body, usually incidentally or through nonspecific symptoms. A combination of clinical, histological, and immunohistochemical features is required to establish a diagnosis. There are no proper guidelines for the treatment of SFTs because of their rarity; however, wide surgical excision remains the "gold standard". A multidisciplinary team approach is recommended. They are mostly benign with a 5-year survival rate of 89%. Following a PubMed-indexed English literature review, only six publications presenting nine cases of breast SFT in a male patient were found. The following is the case of a 73-year-old man who presented with dry cough. A SFT in the right breast was discovered incidentally during the investigative work up, and the patient was referred to our Breast Clinic at the Jules Bordet Institute, Brussels, Belgium, for appropriate treatment. The patient's presentation, imaging, and histological sample all supported the diagnosis, and he underwent uneventful surgical resection. Here, we present the first case of an incidental finding of a SFT of the male breast, with its diagnosis and therapeutic challenges.

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“…As seen in a case report of a female patient with breast SFT, [7] the small lesion may be judged as not necessary for tissue sampling in ultrasound examination. In some cases, [8,9] breast SFTs rapidly increased in size within a year, whether it was benign or malignant; however, in most cases, it gradually gets bigger over several years. Tissue sampling may be worth considering when well-circumscribed hypoechoic lesion showing hypervascularity exhibits a gradual growth in the breast during follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of male breast: A case report and literature review

et al. 2022

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Background: Solitary fibrous tumors (SFT) are uncommon mesenchymal neoplasms which can arise in any anatomical location. Pleural SFTs have been most frequently documented; however, breast SFT is an exceedingly rare entity and seldom present in male breast, with only 8 previously reported cases. Recently, STAT6 immunostaining was considered to be a definitive marker of SFT, however, no case of the male breast SFT showing STAT6 positivity preoperatively has been reported. Methods and Results: We describe a case of breast SFT in a 73-year-old male patient with a 12-month history of a palpable breast mass. The only associated clinical symptom was bilateral gynecomastia. An ultrasound scan examination revealed an oval, well-circumscribed and hypoechoic mass with hypervascularity. A core-needle biopsy was performed, and microscopic examination with immunohistochemistry confirmed the diagnosis of SFT. He underwent a complete surgical resection with clear margins, and there were no signs of high cellularity, remarkable mitotic activity, pleomorphism, hemorrhage or necrosis. Conclusion: A perioperative immunohistochemical evaluation for diffuse and intense nuclear expression of STAT6 was helpful to distinguish SFT from myofibroblastoma. We, herein, describe the first case of SFT in a male breast, confirmed by STAT6 immunostaining positivity. We also conducted a literature review of all previous cases of breast SFTs.

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Solitary fibrous tumor of the breast: A rare neoplasm

Cited by 6 publications

References 0 publications

A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

Incidental finding of solitary fibrous tumor of male breast: case report and review of literature

Solitary fibrous tumor of male breast: A case report and literature review

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