Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings

Abstract

The specimen consisted of fragmented, darkred, soft hemor rhagic tissue, measuring 0.8×0.4×0.3 cm. The specimen was fixed in 10% formalin. Microscopically, the tumor was well de marcated from the overlying squamous epithelium, with no A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.

Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis

“…A SFT is an uncommon type of spindle-cell mesenchymal tumor. It is most commonly found in the visceral pleura, but also has been reported in virtually all extrapleural soft tissues [ 5 , 8 ]. Recently, SFTs and HPCs in soft tissue have been reclassified as a single entity [ 3 ].…”