Solitary Fibrous Tumor of the Orbit With Multiple Cavities

Polomsky, Matej; Sines, Daniel T.; Dutton, Jonathan J.

doi:10.1097/iop.0b013e318279fdd6

Cited by 12 publications

(9 citation statements)

References 10 publications

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“…Painless, non-pulsating, incompressible masses can be touched by physical examination [24]. The patients involved in the current study had a mean age of 54 years old, and their clinical manifestations included exophthalmos, ptosis, abnormal eye position, and blurred vision, which were consistent with those reported previously [24][25][26][27].…”

Section: Clinical Manifestationssupporting

confidence: 82%

Clinicopathological Characteristics of Three Cases with Recurrent Orbital Solitary Fibrous Tumors: A Retrospective Study and Literature Review

Cui¹,

Wang²,

Cui³

et al. 2021

Preprint

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Purpose Solitary fibrous tumor (SFT) is a spindle cell neoplasm that rarely occurs in orbit. This study aimed to report clinical, imaging, and pathological features of three patients with recurrent orbital SFTs.Methods Clinical, imaging, and pathological data of the three patients were retrospectively reviewed, and the results were compared with those of previously reported cases with recurrent orbital SFT. Results One female and two male patients (mean age, 54 years old) were included in this study. The present cases and literature review showed that the average time to recurrence in patients who aged under 50 years old was shorter than that in those who aged over 50 years old. The most common site for recurrent orbital SFT was the retrobulbar area of the orbit (23.8%). Imaging examinations showed consistent intensity of MRI signals before and after recurrence. Immunohistochemical results of all cases revealed the expressions of CD34. The mitotic rate increased in 4/8 cases, and the percentage of Ki-67-positive cells was elevated in 5/16 cases. Conclusion These results suggested that young patients were more likely subjected to recurrent orbital SFT. The postoperative pathological diagnosis revealed that patients with recurrent orbital SFT had more nuclear abnormalities and mitotic activity, as well as a higher percentage of Ki-67-positive cells, indicating that orbital recurrent SFT tended to be malignant according to both morphological features and immunohistochemistry results.

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Section: Clinical Manifestationssupporting

confidence: 82%

Clinicopathological Characteristics of Three Cases with Recurrent Orbital Solitary Fibrous Tumors: A Retrospective Study and Literature Review

Cui¹,

Wang²,

Cui³

et al. 2021

Preprint

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“…2 Although SFT was originally reported to be located within the pleura, 1 case studies from extrapleural sites of SFT have also been reported. [4][5][6][7][8][9] As SFT is an extremely rare tumor, its longterm clinical behavior is not known. This case may enlighten the mostly unknown clinical behavior of this tumor.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9] Rarely, it is found in the mediastinum, skin, meninges, orbit, upper respiratory tract, breast, thyroid, and peritoneum. 5 Solitary fibrous tumor exhibits a variable microscopic appearance, which necessitates immunohistochemistry to confirm the diagnosis.…”

mentioning

confidence: 99%

Giant Solitary Fibrous Tumor of Orbit

Tenekeci¹,

Sarı²,

Vayısoğlu³

et al. 2015

Journal of Craniofacial Surgery

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Solitary fibrous tumors (SFTs) have been reported in various locations in the body. Solitary fibrous tumors are extremely rare tumors, especially when located in the orbit. Diagnosis of SFT cannot be made based on histopathology only because it exhibits a variable microscopic appearance, and necessitates immunohistochemistry to confirm the diagnosis. A 51-year-old man was admitted to our clinic for the evaluation of a mass bulging in his left eye. Clinical examination revealed a painless mass extruding out of the orbital cavity with dimensions of 8 × 7 cm. Exenteration of the left eye including the upper and lower eyelid and reconstruction of the orbital cavity using a temporoparietal fascia flap and a temporal muscle flap was performed. SFT of orbital region is known as a slow growing and painless tumor. Based on previous studies, increased mitotic rate of the tumor gives the impression that the tumor has a malignant nature. Until now a small number or orbital SFTs were reported and none of them presented with a giant mass protruding out of the orbital cavity. We present a unique case of orbital SFT filling the whole orbital cavity and protruding outward as a giant mass. This case has been reported to expand our knowledge in this debated entity.

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“…Although orbital SFTs are mostly solid tumours, partial or complete cystic changes have been reported in seven previous cases (three primary and four recurrent), but none of these occurred in the lacrimal gland. [32–36]. Although the mere presence of cavitary lesions does not necessarily indicate aggressive behaviour, cystic degeneration poses a risk of recurrence and may suggest malignant transformation over time, especially in recurrent tumours.…”

Section: Discussionmentioning

confidence: 99%

“…[35]. The mechanism of cystic degeneration is unknown, but it has been suggested that the tumour outgrows its blood supply, leading to necrotic areas that are later reabsorbed, generating cystic spaces [32]. No data are available to establish whether there is a relationship between tumour age and the onset of cystic degeneration.…”

Section: Discussionmentioning

confidence: 99%

Cystic appearance - a new feature of solid fibrous tumours in the lacrimal gland: a case report with literature review

Gheorghișan-Gălățeanu

Terzea

Burcea

et al. 2019

Diagn Pathol

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Background Solitary fibrous tumours (SFTs) rarely occur in the orbit, especially in the lacrimal area. These tumours are mostly solid. Cystic changes have been documented, but they remain very rare. Only three cases of primary orbital solitary fibrous tumours with cystic changes have been reported in the literature, but no cases have been reported to occur in the lacrimal gland. Solitary fibrous tumours generally follow a benign course and are treated definitively with surgical excision. Data from the literature suggest that the cystic nature of SFT presents a risk of recurrence and could be a harbinger of malignancy. Case presentation A 42-year-old woman was admitted to the endocrinology department for right unilateral exophthalmia and epiphora in the last 8 months. An ophthalmological evaluation showed exophthalmia only in the right eye (22 mm) and normal visual acuity, visual field and extraocular movements. Investigations revealed normal thyroid function. Orbital magnetic resonance imaging detected a 4 × 2,2 × 2,7 cm septate pseudocystic mass in the right lacrimal gland. Given her lacrimal gland tumour diagnosis, the patient was submitted for neurosurgical intervention with total ablation of the tumoural mass and complete right dacryoadenectomy. Although the intraoperative extemporaneous examination results were suggestive of a haemangiopericytoma, histological and immunocytochemical examination showed an extrapleural SFT. The postoperative clinical evolution was favourable, with remission of the exophthalmia. Fifteen months after surgery, no signs of recurrence were noticed. Conclusions We report the first case of an SFT with cystic changes in the lacrimal gland. Although the presence of cavitary lesions alone does not necessarily indicate aggressive behaviour, cystic changes pose a risk of recurrence and may suggest malignant transformation over time. As a result, our case requires long-term follow-up due to recurrence and malignant potential.

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Solitary Fibrous Tumor of the Orbit With Multiple Cavities

Cited by 12 publications

References 10 publications

Clinicopathological Characteristics of Three Cases with Recurrent Orbital Solitary Fibrous Tumors: A Retrospective Study and Literature Review

Clinicopathological Characteristics of Three Cases with Recurrent Orbital Solitary Fibrous Tumors: A Retrospective Study and Literature Review

Giant Solitary Fibrous Tumor of Orbit

Cystic appearance - a new feature of solid fibrous tumours in the lacrimal gland: a case report with literature review

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