Solitary fibrous tumor of the liver. Case report and review of the literature

Bejarano-González, Natàlia; García-Borobia, Francisco; Romaguera-Monzonís, Andreu; García-Monforte, Neus; Falcó-Fagés, Joan; Bella, María Rosa; Navarro‐Soto, Salvador

doi:10.17235/reed.2015.3676/2014

Cited by 12 publications

(20 citation statements)

References 15 publications

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“…Findings on MRI are similar to that of CT scans. In T1WI, the SFTL demonstrates a heterogeneous mass with hypointense signals compared to the normal hepatic parenchyma which is thought to reflect the high content of collagenous tissue [39, 40]. A heterogeneous mass that may be both hypo- and hyperintense is observed in T2WI with some areas described as almost isointense to cerebrospinal fluid [18, 41].…”

Section: Discussionmentioning

confidence: 99%

“…Percutaneous biopsy for tissue diagnosis prior to resection is a much debated topic but is a well-documented approach in the lead up to the resection of SFTLs [3, 16, 18, 27, 28, 31, 40, 43–47]. Given the many risks it poses—including seeding the tumour via the needle tract [4, 48], pain, intrahepatic or subcapsular haematoma and bile leaks [4]—it is doubtful whether preoperative biopsy would change management if the lesion is able to be safely resected [24].…”

Section: Discussionmentioning

confidence: 99%

“…On the cut surfaces, they are well documented to be firm and difficult to cut with a whorled bulging appearance interspersed with central areas of scarring and radiating bands of fibrous tissue. Some SFTLs may also display features of myxoid degeneration [3, 22, 26, 40, 50], necrosis [20, 27, 28, 35, 42, 51, 52], haemorrhage [20, 51] or cystic cavitation [2, 24, 29, 34, 35, 40, 42, 53]. …”

Section: Discussionmentioning

confidence: 99%

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Solitary fibrous tumour of the liver—report on metastasis and local recurrence of a malignant case and review of literature

Chen

Slater

2017

World J Surg Onc

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BackgroundSolitary fibrous tumours (SFT) are neoplasms of mesenchymal origin that predominantly arise from the pleura. SFT of the liver (SFTL) are a rare occurrence with little number of cases reported in English literature. Malignant cases of hepatic SFT are an even rarer occurrence. For this reason, the prognostic evaluation of SFTLs is unknown and difficult to measure.MethodsA search on English literature on “Solitary Fibrous Tumour of the Liver” was conducted on common search engines (PubMed, Google). All published articles, case reports and literature reviews and their reference lists were reviewed.Case reportThis paper presents a 61-year-old male who was referred to a tertiary hospital in April 2010 with marked hepatomegaly. USS, CT and MRI scans were suggestive of a neoplasm, and the patient underwent a subsegmental IVb resection in June 2010. The specimen demonstrated histological and immunohistochemical features of malignant SFTL with clear resection margins. The patient was followed up regularly for 3 years with imaging and no suggestion of recurrence. Six years after the initial surgery, the patient represented with worsening right upper quadrant pain and dyspnoea secondary to extensive tumour recurrence adjacent to the resection site and metastatic deposits in the pleura. The patient was managed symptomatically and discharged for community follow-up after palliative involvement.ConclusionsSFTL are rare with only 84 cases reported in the English Literature including the present case. The average age of patients is 57.1 and occurs in females more than males (1.4:1). Most SFTLs follow a benign course, however, 17.9% of cases displayed malignant histological features. Only three cases including the current case are reported to have both local recurrence and metastasis. Surgical resection remains the mainstay of treatment and appears to be curative of most cases. The rarity of this tumour makes it difficult to evaluate its prognosis and natural course.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Solitary fibrous tumour of the liver—report on metastasis and local recurrence of a malignant case and review of literature

Chen

Slater

2017

World J Surg Onc

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“…So far, no specific laboratory markers have been suggested for the diagnosis of hepatic SFT. Based on MRI findings, hypointense signals with a heterogeneous mass, which may be observed along with calcification, indicate a high content of collagenous tissue in T1 weighted image, and heterogeneous masses including hypo or hyperintense or both of them in T2 weighted are observable in patients with SFT of the liver [18,19].…”

Section: Discussionmentioning

confidence: 99%

A Giant Solitary Fibrous Tumor of the Liver with Metastasis and Local Recurrence

Hoseini

Fahimi

Vaziri

et al. 2020

JPRI

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Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm. Although the majority of SFTs are benign, some cases have shown characteristics of malignant neoplasms. Weight loss, fatigue, and upper abdominal bloating are the main signs of these lesions. Clinical and radiographic features are not sufficient for the diagnosis of hepatic SFT and the definitive diagnosis depends on histopathological sampling and immunohistochemistry. One of the main issues in the diagnosis of this tumour is the ability of this tumour to grow to large sizes. A 69-year-old male presented to the clinic 2 years earlier with episodes of hypoglycemia and loss of consciousness. The symptoms improved after receiving glucose. The patient diagnosed as rare solitary fibrous tumour of the liver, a giant (10 × 10 cm in diameter) round and well-defined lesion in the left lobe of the liver which was obvious in magnetic resonance imaging (MRI). Surgery is the most common line of treatment for this disease and there is no evidence regarding the effectiveness of other approaches. According to the scarcity of hepatic SFT, long-term prognosis in these patients is highly challenging. Here, we present the case of a 69-year-old male patient with hepatic SFT with metastasis and local recurrence. In the very rare malignant form of liver solitary fibrous tumour which is surgically unresectable, liver transplantation is one of the potential options but maybe not amenable due to the malignant behaviour of the disease. Role of debulking surgery is also not clear in this situation.

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“…First described in the year 1931, SFT is a rare neoplasm primarily occurring in pleura. 1 , 3 Although it has been reported in other extrathoracic sites, the occurrence in liver is particularly rare. 1-3 Bejarano and colleagues have enlisted 51 cases of hepatic SFT.…”

Section: Discussionmentioning

confidence: 99%