Solitary fibrous tumor of the breast: A case report and review of the literature

Tsai, Shu-Ya; Hsu, Chih‐Yi; Chou, Yi‐Hong; Lai, Yi‐Chen; Lin, Yung-Hui; Wang, Hsin‐Kai; Chiou, Hong‐Jen; Wang, Jane; Tiu, Chui‐Mei

doi:10.1002/jcu.22415

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…6 Elastography on the US is not hard. 3 Breast SFT can be shown as a relatively well-defined mass without calcifications on mammography, 9,19 and this lesion was radiologically classified under the BI-RADS category 3 18,19 or category 4. 2,10 While malignant SFTs often presented a focal lobulated appearance 3,6,21 and were often classified as BI-RADS 4C by radiologists.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

et al. 2022

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Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm which may arise in a wide range of anatomic location and can occur across all ages. Fat-forming SFT is a rare morphological variant of SFT. Primary breast fat-forming SFT is exquisitely rare. Here, we report a case in a 51-year-old Chinese woman with a palpable painless mass in the left breast. A color Doppler ultrasound scan examination demonstrated a 3.4-cm oval, well-circumscribed, hypoechoic solid mass with several peripheral and internal color flow signals. Magnetic resonance imaging (MRI) showed a focal lobulated solid nodular lesion displaying geographical enhancement but no architectural distortion. Subsequently, she underwent a left breast lumpectomy. In histopathologic examination, there was a well-circumscribed, cellular spindle cell tumor consisting of short fascicles of bland, fusiform, ovoid to spindle cells disposed in a patternless architecture around branching vascular spaces within a fibrous stroma with wispy collagen. Cells revealed mild nuclear atypia. Mitotic figures were up to 4/10 high-power fields (HPFs) in the hot spot. Mature adipocytes intermixed with spindle cells were also observed. The tumor cells were diffusely positive for CD34 and STAT6. Some S100-expressing adipocytes co-expressed STAT6. Next-generation sequencing (NGS) revealed the presence of the NAB2exon6::STAT6exon2 fusion. The histological, immunohistochemical (IHC) and molecular examinations confirmed the diagnosis of fat-forming SFT. Post-excision, the patient showed no signs of tumor recurrence or metastasis in a 7-month follow-up. Here, we describe a rare case of a fat-forming SFT involving the breast and highlight the comprehensive pathological evaluation and necessary ancillary testing.

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Section: Discussionmentioning

confidence: 99%

“…1 To date, only 33 cases of breast SFT have been reported in the previous English literature, of which only 1 case was fat-forming SFT (summarized in Table 1). 2–28 Here, we report a case of breast fat-forming SFT with focal atypical features. We also reviewed the clinical features and diagnostic hallmarks of breast fat-forming SFT.…”

Section: Introductionmentioning

confidence: 91%

A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

et al. 2022

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“…It has been known to occur most frequently in the pleural cavity, but it has also been described in other sites -such as the retroperitoneum, abdominal cavity, proximal extremity, and head and neckwhich could have occurred owing to the increased recognition of this entity (3). Among the extrapleural sites, SFTs in the breast have only been reported in 23 cases, which is rare (3)(4)(5)(6)(7)(8)(9). Moreover, involvement of the male breast is rarer, and only a few cases have been reported (4,5).…”

Section: Discussionmentioning

confidence: 99%

“…Solitary fibrous tumor (SFT), an uncommon neoplasm that has been found most commonly in the pleura but may also arise at various extrapleural sites, including the head, neck, lung, abdomen, pelvis, and extremities was first described as a primary spindle-cell tumor of the pleura by Klemperer and Rabin in 1931 (1,2). SFT in the breast is very rare; only 23 cases have been reported in the medical literature (3)(4)(5)(6)(7)(8)(9). Herein, we report a case of breast SFT in a 64-yearold man.…”

Section: Introductionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Male Breast: A Case Report with Imaging Findings

et al. 2018

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Solitary fibrous tumor (SFT) is an uncommon neoplasm of mesenchymal origin, and it most often occurs in the pleura. Mammary gland involvement is extremely rare in this disease. Herein, we report a case of SFT that presented as a slowly growing large mass in the breast of a 64-year-old man. On ultrasonographic examination, the mass was oval and circumscribed with heterogeneous echogenicity and increased intralesional blood flow. Moreover, the mass showed hard elasticity as revealed by shear-wave elastography (SWE), which has not been reported in English literature so far. We also briefly review the literature on the radiologic findings. Because of the nonspecific imaging findings and difficulty in its differentiation from other soft tissue tumors, complete excision with detailed immunohistochemistry is essential.

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“…The onset of SFTs is insidious with no obvious symptoms at early stage. [2] As a result, the diagnosis is somewhat difficult to ascertain at an early stage. [3] For accurate results, the diagnosis of SFTs must always depend on histopathology.…”

Section: Introductionmentioning

confidence: 99%

Clinical and pathological analysis of solitary fibrous tumors with portal vein widening

Wang

Yang²,

Chen³

et al. 2019

Medicine

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Rationale: Solitary fibrous tumors (SFTs) are rare soft-tissue tumors characterized with spindle-cell, which occur more common in the chest and rarely seen in the abdomen. So far as we knew, SFTs accompanied with venopathy of portal vein has rarely been reported. Patient concerns: A 36-year-old male presented with left-sided abdominal mass and portal vein expansion on ultrasound. Diagnoses: The post-operative histopathology confirmed the diagnosis of Solitary fibrous tumor. Interventions: Laparotomy was performed and the mass was completely removed. Outcomes: Patients had no symptoms, recovered well without recurrence; the portal vein and splenic vein dilatation were alleviated and the symptoms of portal hypertension were relieved. Lessons: SFTs presents with few symptoms in the early stage of the disease. A rich arteriovenous shunt is beneficial to the diagnosis of SFTs by B-ultrasound and computed tomography (CT) examinations. However, the diagnosis of SFTs must depend on histopathology.

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Solitary fibrous tumor of the breast: A case report and review of the literature

Cited by 8 publications

References 16 publications

A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

Solitary Fibrous Tumor of the Male Breast: A Case Report with Imaging Findings

Clinical and pathological analysis of solitary fibrous tumors with portal vein widening

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