Solitary Fibrous Tumors of the Pleura: A Clinical-pathological Characterization Emphasizing Changes in Lung Function

Mendez-Sanchez, Heron; Mendez-Vivas, Wilbert; Vargas-Mendoza, Gary Kosai; Vázquez-López, Saúl; Williams-Jacquez, Angela Dayana; Cortés-Télles, Arturo

doi:10.5603/arm.a2019.0042

Cited by 7 publications

(11 citation statements)

References 10 publications

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“…At the same time, the transmural pressure gradient decreased, which affected the ventilation/perfusion ratios and, therefore, gas exchange;this is a different reason for dyspnea. Also, the authors believe that lung function and CT scans are excellent objective indicators for follow-up (35).…”

Section: Discussionmentioning

confidence: 95%

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Zuo¹,

Zhou²,

Sun³

et al. 2020

Ann Transl Med

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A solitary fibrous tumor (SFT) is a rare spindle cell tumor-derived from mesenchymal cells. It may be linked to the fusion of the NAB2-STAT6 gene caused by 12q chromosome rearrangement. It can occur in the connective tissue of any part of the body; however, it is most common in the pleura. Solitary fibrous tumors of the pleura (SFTP) are a persistent painless mass with slow growth. With the increase of the tumor, there will be corresponding compression symptoms. Pleural effusion is rare, and the cytology of pleural effusion is mostly negative. Occasionally, SFTP can induce paraneoplastic syndrome, distant metastasis, and malignant transformation. Lung function may have mild to moderate restrictive ventilation dysfunction. CT is a crucial method for the clinical diagnosis of SFTP. The histopathological features of SFTP are the coexistence of sparse and dense areas. CD34, CD99, Bcl-2, and vimentin are the most valuable immunohistochemical markers.The positive expression rate of STAT6 in benign SFT was even 100%. Adhesion or unclear boundary with surrounding tissues, pleural effusion or calcification, tumors with a maximum diameter greater than 10 cm, invasive growth, uneven density, metastasis or recurrence, paraneoplastic syndrome, moderate to severe cell heterogeneity, high Ki67 proliferation index, and low STAT6 expression suggest SFTP may be a malignant tumor. Gene analysis on next generation sequencing may help reveal the mutation characteristics of SFTP. Complete tumor resection is the gold standard of SFTP. Resectability is the most important prognostic factor. Age, size, mitosis, and necrosis are considered risk stratification factors for prognosis. Fortunately, 80% of SFTP are benign and have anexcellentprognosis but need long-term follow-up.We report a case of rapidly growing tumor with pleural effusion within 9 months, who was surgically treated and is currently under follow-up. And the literature is reviewed.

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Section: Discussionmentioning

confidence: 95%

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Zuo¹,

Zhou²,

Sun³

et al. 2020

Ann Transl Med

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“…La relación de tumores benignos a malignos es de 7:1 (2,7). Se estima que tienen una incidencia de 2.8 casos por 100.000 pacientes hospitalizados registrados (6,8). La mayoría de los tumores son únicos, aunque ocasionalmente se han reportado casos de múltiples tumores en cavidad pleural (6).…”

Section: Discussionunclassified

“…El TSFP parece ser más frecuente en hombres (8), aunque algunos autores lo han encontrado con distribución similar entre los sexos (3,5,8,7) o más frecuente en mujeres (2,13,6), la mayoría de ellos siendo diagnosticados después de la sexta década de la vida (3,5,8). No se conocen con certeza factores de riesgo para el desarrollo de este tipo de tumor, excepto en un caso reportado que sugiere origen genético (2).…”

Section: Discussionunclassified

“…No se conocen con certeza factores de riesgo para el desarrollo de este tipo de tumor, excepto en un caso reportado que sugiere origen genético (2). En población hispánica se han descrito casos por debajo de los 50 años hasta en 20 % de los casos (3,8). Los TSFP pueden alcanzar tamaños importantes antes de presentar síntomas, siendo descritos tumores desde 2.5 cm y 64 gr de peso hasta de 45 cm y 3.8 kg de peso (2,8,13) o incluso hasta 6.9 kg (14).…”

Section: Discussionunclassified

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Tumor fibroso solitario de mediastino anterior adherido a pericardio. Reporte de un caso

Giraldo

2022

rev. colomb. neumol.

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Se presenta el caso de un paciente de 82 años, con tumor intratorácico de crecimiento rápido, con aumento progresivo de la disnea, antecedentes de enfermedad coronaria y baja función cardíaca, obesidad y síndrome de apnea de sueño, quien fue sometido a toracotomía y a quien se le diagnosticó un tumor solitario fibroso de la pleura, tumor de muy baja frecuencia, adherido en forma sésil al pericardio, lo cual lo hace aún menos frecuente. Se hace una revisión general de las posibilidades terapéuticas, el diagnóstico histológico y por inmunohistoquímica, así como los criterios de benignidad y malignidad para este tipo de tumor, que son en su mayoría de buen pronóstico.

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“…PSFTs are not as common as other types of pleural tumors, such as diffuse malignant pleural mesothelioma. They account for less than 5% of cases of pleural tumors and are more frequently encountered in men, during the sixth or seventh decade of their life [12]. Other authors consider it more common in women, with a proportion of 1:1.35 [11].…”

Section: Discussionmentioning

confidence: 99%

Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

et al. 2020

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Introduction: The purpose of this paper is to study the type, the clinical presentation, and the best diagnostic methods for pleural solitary fibrous tumors (PSFTs), as well as to evaluate which is the most appropriate treatment, especially as PSFTs represent a rare occurrence in the thoracic pathology. Material and Method: A retrospective study was conducted on a group of 45 patients submitted to surgery between January 2015 and December 2019. In most cases, the diagnosis was established through imaging studies—thoracic computed tomography (CT) scan with or without contrast—but also using magnetic resonance imaging (MRI) or positron emission tomography (PET) scans when data from CT scans were scarce. All patients were submitted to surgery with curative intent. Results: Most patients included in this study were asymptomatic, with this pathology being more common in patients over 60 years of age, and more common in women. The occurrence of malignant PSFT in our study was 17.77% (8 cases). All cases were submitted to surgery with curative intent, with a single case developing further recurrence. In order to achieve complete resection en bloc resection of the tumor with the chest wall, resection was performed in two cases, while lower lobectomy, pneumectomy, and hemidiaphragm resection, respectively, were needed in each case. Postoperative mortality was null. Conclusion: Thoracic CT scan remains the most important imagistic investigation in diagnosing. MRI is superior to thoracic CT, especially in cases that involved the larger blood vessels within the thorax, spinal column, or diaphragm. Complete surgical resection is the gold standard in treatment of PSFT, and the prognosis in benign cases is very good.

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Solitary Fibrous Tumors of the Pleura: A Clinical-pathological Characterization Emphasizing Changes in Lung Function

Cited by 7 publications

References 10 publications

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Tumor fibroso solitario de mediastino anterior adherido a pericardio. Reporte de un caso

Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

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