Solitary fibrous tumors of the orbit and central nervous system: A case series analysis

Abstract

Introduction:Solitary fibrous tumor (SFT) is rarely diagnosed in clinical practice. Since its initial descriptions in the central nervous system (CNS) and the orbits, very few case reports and small case series have expanded their clinical and pathological characterization. We sought to describe a cases series of SFT from a single laboratory of neuropathology belonging to a tertiary university hospital.Methods:Retrospective clinical and histopathological description of eight cases of CNS and orbital SFT diagnosed over a 21-year period of time.Results:Median age was 47.3 years and four were males. Clinical presentation was related to local mass effect in all. Tumors occurred in the orbits (5/62.5%), intracranial dura attached (2), and the spinal medulla (1). The neuropathology showed the presence of hemangiopericytoma type (2), classic type (3), and mixed type (3). Histological anaplasia was present in two cases. Widespread/total immunoreactivity for vimentin, CD34, and Bcl-2 was present in all. Gross total removal was conducted in the majority (6/75%) and subtotal removal in 2 (25%). Three patients were submitted to adjuvant treatment (radiosurgery and radiotherapy). Recurrence occurred in four patients, 13–120 months after surgical intervention. Anaplasia was present in one case of recurrence.Conclusion:Our case series confirms the clinical and neuropathological diversity of CNS and orbital SFTs. Studies with longer follow-up periods are necessary to better understand the clinical behavior and prognosis of the SFT in the CNS and orbits.

Intraorbital solitary fibrous tumor requiring preoperative embolization of feeding artery

“…[4] Therefore, the most effective treatment for SFT is surgical removal of the tumor to the maximum possible extent. [1467] In addition, the hemodynamic characteristics must be understood to minimize the risk of intraoperative hemorrhage. In cases involving large tumors, intratumoral blood flow is often abundant, which makes it difficult to remove the tumor; therefore, preoperative embolization is recommended.…”

“…In addition, radiation and chemotherapy are both ineffective; consequently, complete excision is necessary for cure. [1367] In general, large SFTs are often highly vascular, and preoperative embolization is required to control intraoperative bleeding. [38] However, due to the risk of complications such as loss of visual acuity, reports describing embolization of orbital tumors are very few.…”

Cystic appearance - a new feature of solid fibrous tumours in the lacrimal gland: a case report with literature review

“…Similar to other locations, SFTs occurring in the lacrimal fossa can histologically mimic haemangiopericytoma [13]. The histological differentiation of these two types of lesions is difficult because cases of haemangiopericytoma can show features of SFT and vice versa [14–16]. Many pathologists consider haemangiopericytoma and solitary fibrous tumour to represent a continuum of tumours [17].…”

Factors for postoperative recurrence of orbital solitary fibrous tumor: an analysis of long‐term clinical follow‐up results from a Chinese tertiary hospital

“…Then more and more neurosurgeons and ophthalmologists recognized and reported such tumor [ 4 – 8 ], SFT tumor is extremely rare in the orbit. Intra-orbital OSFT is extremely rare, and cranio-orbital OSFT is even rarer [ 9 – 11 ]. There are a few related reports in many literatures.…”