Solitary fibrous tumour of the central nervous system: pathological study of eight cases and review of the literature

Mekni, Amina; Kourda, J; Hammouda, Karim Ben; Tangour, Monia; Kchir, Nidhameddine; Zitouna, Moncef; Haouet, Slim

doi:10.3109/00313020903071439

Cited by 22 publications

(24 citation statements)

References 33 publications

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“…Calcifications are rarely documented. 108,132,156,163,176 Contrast-enhanced CT and MRI reveal heterogeneous or homogeneous enhancement, best appreciated on T1-weighted MR images (Figs. 1, 2).…”

Section: Frequency Demographics Clinical Manifestations Preoperatimentioning

confidence: 95%

“…2,3,6,13,207,218 Each of these atypical morphological features may be discernable in isolation or in various combinations. To date, at least 29 cases (13.18%) of SFT of CNS exhibiting 1 or more atypical features at presentation, 14,64,[86][87][88][89]91,94,101,104,109,110,112,116,129,136,139,156,164,171,174,176 and 5 tumors showing atypical features at recurrence 17,77,83,108,173 have been reported ( Table 1). The atypical features in the majority of the aforementioned cases were diffuse.…”

Section: Atypical and Malignant Typesmentioning

confidence: 98%

“…Although rare, unfavorable outcome is on record. In our review, we found 26 cases with local recurrences (even multiple recurrences over many years), 15,64,101,112,116,125,126,137,139,152,156,[172][173][174]176 2 cases of meningeal spread through cerebrospinal fluid dissemination, 117,127 and 5 cases with extracranial metastases, usually after recurrence. 83,108,110,139,147 Extracranial metastatic deposits, which were specified in 4 cases, occurred in the soft tissue of the neck and chest wall, 83 viscera (lung, 83,108,110,147 and liver 108,147 ), and bone.…”

Section: Biological Behavior and Prognostic Factorsmentioning

confidence: 99%

“…Although most intracranial SFT (148 of 170) were extra-axial dural-based tumors, 22 (accounting for 12.94%) had no apparent connection with the dura. Of the latter, 13 were intraventricular, 90,103,105,108,132,133,135,142,146,156,157,169,172 occasionally found attached to the choroid plexus, 108,135,172 3 were parenchymal lesions deeply located in the brain substance, 91,94,108 5 arose from the proximal (intradural) segment of the cranial nerves, 65,97,99,131,167,168 and 1 at the cerebello-pontine angle 139 (Table 1). [We did not include in our tabulation the following cases: 7 cases of meningeal SFT 76,100,107,145,154 Of the 42 cases for which the exact location was stated, in decreasing order of frequency, 20 were thoracic (including 1 epidural lesion metastatic from an intracranial primary initially diagnosed as fibrous meningioma), 108 (Table 1 intraspinal cases marked with an asterisk).…”

Section: Histogenesis Anatomical Locations Gross Featuresmentioning

confidence: 99%

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Solitary Fibrous Tumor of the Central Nervous System

Bisceglia

Galliani

Giannatempo³

et al. 2011

Advances in Anatomic Pathology

100

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We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.

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Section: Frequency Demographics Clinical Manifestations Preoperatimentioning

confidence: 95%

Section: Atypical and Malignant Typesmentioning

confidence: 98%

Section: Biological Behavior and Prognostic Factorsmentioning

confidence: 99%

Section: Histogenesis Anatomical Locations Gross Featuresmentioning

confidence: 99%

See 2 more Smart Citations

Solitary Fibrous Tumor of the Central Nervous System

Bisceglia

Galliani

Giannatempo³

et al. 2011

Advances in Anatomic Pathology

100

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“…Histologically, they are well circumscribed masses predominantly populated by spindle cells with abundant extracellular collagen. Distinct immunohistochemical features characterize these tumours which include diffuse CD34 positivity and epithelial membrane antigen negativity [34] (Figure 5). Some tumours may show hypocellular areas with profuse extracellular collagen deposition alternating with hypercellular areas [35] .…”

Section: Solitary Fibrous Tumourmentioning

confidence: 99%

Benign neck masses showing restricted diffusion: Is there a histological basis for discordant behavior?

Das

Bhalla

Sharma

et al. 2016

WJR

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Diffusion weighted imaging (DWI) evolved as a complementary tool to morphologic imaging by offering additional functional information about lesions. Although the technique utilizes movement of water molecules to characterize biological tissues in terms of their cellularity, there are other factors related to the histological constitution of lesions which can have a significant bearing on DWI. Benign lesions with atypical histology including presence of lymphoid stroma, inherently increased cellularity or abundant extracellular collagen can impede movement of water molecules similar to malignant tissues and thereby, show restricted diffusion. Knowledge of these atypical entities while interpreting DWI in clinical practice can avoid potential misdiagnosis. This review aims to present an imaging spectrum of such benign neck masses which, owing to their distinct histology, can show discordant behavior on DWI.

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Solitary Fibrous Tumors

Geib

Furlanetto

2012

Tumors of the Central Nervous System, Volume 10

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Solitary fibrous tumour of the central nervous system: pathological study of eight cases and review of the literature

Cited by 22 publications

References 33 publications

Solitary Fibrous Tumor of the Central Nervous System

Solitary Fibrous Tumor of the Central Nervous System

Benign neck masses showing restricted diffusion: Is there a histological basis for discordant behavior?

Solitary Fibrous Tumors

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