Solitary fibrous tumour of the spine: imaging features of a commonly misdiagnosed entity

Lang, Nada; Zhang, Enlong; Xing, Xiaoying; Yuan, Huishu

doi:10.1007/s00330-018-5349-7

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…In our study, SFTs demonstrated well-defined homogeneous masses with or without bony destruction on CT, and calcifications were rarely observed, which is consistent with previous studies 5,8,10 . However, the characteristics on MRI were partly different from those reported in previous studies 8,9,12 .…”

Section: Discussionsupporting

confidence: 90%

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Solitary Fibrous Tumor of the Spine: Imaging Grading Diagnosis and Prognosis

Shen

Ren

Wang

et al. 2022

J Comput Assist Tomogr

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ObjectiveThis study aimed to investigate the imaging features and prognosis of spinal solitary fibrous tumors (SFTs) of different pathological grades.MethodsThe clinical features, computed tomography and magnetic resonance (MR) images, and follow-up data of 23 patients with SFTs were reviewed. The patients were divided into 3 groups according to their pathological manifestations: grade 1 (n = 3), grade 2 (n = 14), and grade 3 (n = 6). The following imaging features were recorded: location, computed tomography density/MR intensity, enhancement pattern, dural tail sign, adjacent bone remodeling, lobulation, and tumor size. The immunohistochemical (Ki-67/MIB-1) levels were also investigated. All parameters were statistically analyzed between grade 2 and 3 tumors.ResultsThe Ki-67/MIB-1 index was markedly higher in grade 3 tumors than in grade 2 tumors (P < 0.001). All grade 1 lesions appeared hypointense on T2-weighted image, whereas grade 2 and 3 lesions appeared isointense or mildly hyperintense. There were significant differences in enhancement type and osteolytic bony destruction between grade 2 and 3 tumors (P < 0.05). However, no marked differences were found in the distribution of age, sex, location, MR signal, degree of enhancement, compressive bony absorption, dural tail sign, or maximum vertical/traverse diameter ratio. Malignant progression occurred less frequently in patients with grade 2 tumors than in those with grade 3 tumors, but the difference was not statistically significant.ConclusionsDifferent grades of spinal SFTs have different degrees of proliferation and imaging features, especially grade 3 tumors, which show a heterogeneous enhancement pattern, osteolytic bony destruction, and a higher possibility of recurrence and metastasis.

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Section: Discussionsupporting

confidence: 90%

“…5 To the best of our knowledge, only a few cases of spinal SFTs have been reported in the literature. [5][6][7][8][9][10][11][12] Given the rarity of this disease, its imaging characteristics remain unclear.…”

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confidence: 99%

Solitary Fibrous Tumor of the Spine: Imaging Grading Diagnosis and Prognosis

Shen

Ren

Wang

et al. 2022

J Comput Assist Tomogr

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“…12 SFT is considered to be rare as a cause of dumbbell tumor: only 16 cases were reported before, and 4 of 16 were malignant, to our knowledge. 8,9,13,14 As for our case, we consider it is quite difficult to differentiate MSFT from other more common dumbbellshaped tumor such as schwannoma by clinical presentation. And imaging findings might be of little help.…”

Section: Discussionmentioning

confidence: 82%

“…12 SFT is considered to be rare as a cause of dumbbell tumor: only 16 cases were reported before, and 4 of 16 were malignant, to our knowledge. 8,9,13,14…”

Section: Discussionmentioning

confidence: 99%

“…15 However, recurrence rate of MSFT in CNS even after gross total resection may be considered very high and estimated as 75% (three of four cases) reported in the literature including this case. 14 Prognosis of relapsed MSFT is considered very poor, because salvage surgery may be usually impracticable to perform gross total resection due to their proximity to the OARs in addition to adverse effect caused by prior surgery. Moreover, MSFT has histologically chemoradio-resistant nature which yields poor outcome in local disease control and overall survival for patients with unresectable relapsed MSFT.…”

Section: Discussionmentioning

confidence: 99%

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Salvage carbon ion radiotherapy for recurrent solitary fibrous tumor: A case report and literature review

Murata

Endo

Aihara

et al. 2020

J Orthop Surg (Hong Kong)

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Background: Malignant solitary fibrous tumor (MSFT) arising from the spinal cord is extremely rare and poorly understood mesenchymal neoplasms: only a few MSFT in the spinal canal has been described. We describe the clinical course of the patient with MSFT arising from the thoracic spinal cord. Case report: We describe the clinical course of the patient and the radiological and pathological findings of the tumor. The tumor had been resected by microscopic posterior approach and video-assisted thoracic surgery, but local recurrence was observed by MRI at 1-year follow-up period. No metastatic lesion was confirmed. Then, carbon ion radiotherapy (CIRT) was administered to the recurrent lesion. Local suppression has been observed for 40 months after irradiation. Conclusion: Dumbbell-shaped MSFT arising from thoracic spinal cord is a highly unusual presentation. CIRT might be effective for treatment of recurrent tumors.

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