Solitary fibrous tumour: Report of two new locations in the upper respiratory tract

Safneck, Janice R.; Alguacil-Garcia, Antonio; Dort, Joseph C.; Phillips, Susan M.

doi:10.1017/s0022215100122777

Cited by 80 publications

(54 citation statements)

References 8 publications

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“…Solitary fibrous tumours have also been reported in the abdomen, liver, peritoneum, retroperitoneum, meninges, orbit, thyroid, salivary gland and the soft tissues including the breast [32,33,35]. The upper respiratory tract may be the preferred extrathoracic location, with many documented reports of localized fibrous tumours arising in the nose, paranasal sinuses, parapharyngeal tissues, nasopharynx and epiglottis [32,36].…”

Section: Pathogenesismentioning

confidence: 99%

Solitary fibrous tumours of the pleura

Arab

2011

European Journal of Cardio-Thoracic Surgery

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SummarySolitary fibrous tumours of the pleura are rare. They are mesenchymal in origin. Initially, they were described in the pleura, but lately they have been reported in many other sites. Although the majority of these tumours are benign, some of them are malignant. Their unpredictable clinical course is probably related to their histological and morphological characteristics. The benign tumours may remain unproblematic for several years before changing into a malignant form. In order to define more accurately the clinical behaviour, diagnosis, management and outcome of these rare tumours, we reviewed the literature with particular attention to clinical presentation, methods of diagnosis, treatment and outcome. Furthermore, a modified algorithm was proposed for the management of these tumours.

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Section: Pathogenesismentioning

confidence: 99%

Solitary fibrous tumours of the pleura

Arab

2011

European Journal of Cardio-Thoracic Surgery

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“…SFTs can also be found in various head and neck sites. Although rare, these locations have included the infratemporal fossa, parapharyngeal space, nose and paranasal sinuses, soft palate, epiglottis, as well as the thyroid, parotid, and submandibular gland [2][3][4][5][6][7][8][9][10]. Complete resection is the treatment of choice.…”

Section: Introductionmentioning

confidence: 99%

A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings

et al. 2009

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We present the imaging and pathological features of a 38-year-old man in whom a large parapharyngeal solitary fibrous tumor (SFT) on the left side was found. On MRI, the tumor showed a nodule-in-nodule appearance. The inner nodule revealed high signal intensities both on T1-and T2-weighted MR images. The entire tumor showed heterogeneous enhancement on gadolinium-enhanced T1-weighted images. Imaging features of SFT arising in the parapharyngeal space are discussed with a review of literatures. This is the first report of FDG-PET finding of SFT arising in the head and neck. More cases are needed to achieve diagnostic significance from FDG-PET findings of parapharyngeal SFTs. KEY WORDSsolitary fibrous tumor, parapharyngeal space, MRI, FDG-PET

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“…[1] SFTs may also occur in the peritoneum, mesentery, pericardium, orbit, upper respiratory tract, and meninges. [2][3][4][5][6] The liver is a rare primary site for SFTs with less than 50 cases reported in the English literature. [7][8][9][10][11][12][13][14][15][16][17] Although most cases of SFTs are benign, there have been cases of SFTs with malignant features and metastasis.…”

Section: Introductionmentioning

confidence: 99%

A rare case of primary hepatic solitary fibrous tumor associated with pregnancy

Acosta-Gonzalez

Cho

Rogers

et al. 2016

CRCP

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Purpose: To describe a case of histologically and immunohistochemically confirmed primary hepatic solitary fibrous tumor (SFT) associated with pregnancy. Case report: A 40-year-old Caucasian woman G3P1021 with history of oral contraceptive use and no other known significant past medical history delivered via C-section in November of 2012. Two months post delivery, she noted that her abdomen did not decrease in size and sought medical attention. As part of the work-up, an abdominal MRI revealed a 15.9 cm mass centered in segment 4b of the liver with extension into segments 5 and 8 within the right lobe. In addition, an exophytic component extending inferiorly from the liver into the right mid abdomen was noted. The patient underwent an uncomplicated hepatic segmentectomy with cholecystectomy. Grossly, the tumor consisted of a firm tan-white well-circumscribed and partially encapsulated mass. Histologically, the tumor was composed of cytologically bland spindle cells with a patternless architecture with hypocellular and hypercellular areas embedded within a collagenous fibrous stroma with occasional dilated branching thin-walled blood vessels. The tumor showed no infiltrative margins or necrosis and a mitotic count of 1/10HPF. Tumor cells were strongly and diffusely positive for CD34, BCL-2, and vimentin; weakly positive for STAT6 (nuclear distribution); and focally positive for CD99 and β-Catenin. In addition, estrogen and progesterone receptors (ER and PR) were also performed and showed positive staining. The diagnosis of SFT was confirmed. To date, 36 months post-resection, our patient has been followed with imaging, showing no evidence of residual or recurrent disease. Conclusions: Primary hepatic SFT is exceedingly rare and even more so in association with pregnancy. Positive immunohistochemical staining of tumor cells for progesterone and estrogen receptors may indicate hormonal stimulation as a driver of neoplastic cell proliferation.

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Solitary fibrous tumour: Report of two new locations in the upper respiratory tract

Cited by 80 publications

References 8 publications

Solitary fibrous tumours of the pleura

Solitary fibrous tumours of the pleura

A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings

A rare case of primary hepatic solitary fibrous tumor associated with pregnancy

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