Solitary intracranial plasmacytoma

Mancardi, Gianluigi; Mandybur, T. I.

doi:10.1002/1097-0142(19830615)51:12<2226::aid-cncr2820511213>3.0.co;2-q

Cited by 69 publications

(31 citation statements)

References 22 publications

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“…Classic Reed Sternberg cells and variants, however, lack emperipolesis and S100 immunoreactivity and are typically positive for CD15 and CD30. Intracranial involvement by plasmacytoma is also rare but well documented (31,32). Similar to the case of RDD-CNS, the lesions are attached to the dura and radiographically resemble meningioma.…”

Section: Discussionmentioning

confidence: 69%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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Sinus histocytosis with massive lymphadenopathy, also known as Rosai-Dorfman Disease (RDD), is an idiopathic histiocytic proliferation affecting lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system (CNS) manifestation, particularly in the absence of nodal disease is uncommon. We report 11 cases of RDD primary to the CNS without evidence of other sites of involvement. The cases included 7 males and 4 females ranging in age from 22 to 63 years (mean: 41 y). The patients presented with headaches, seizures, numbness, or paraplegia. Eight cases involved the cranial cavity and three cases, the spinal canal. Lesions were most often extra-axial and dura based. Only one presented in the CNS parenchyma. Histologically, the lesions consisted of variable numbers of pale-staining histocytes with emperipolesis often overshadowed by extensive lymphoplasmacytic infiltrates and fibrosis in the background. Special stains for organisms were negative. By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein and CD68 and negative for CD1a. Treatment consisted of surgical biopsy or excision. Follow-up, available for 10 cases with intervals ranging from 5 days to 42 months (mean: 15 mo), disclosed one patient dying of operative complications 5 days after biopsy and nine patients with no evidence of disease progression RDD should be considered in the differential diagnosis of inflammatory lesions of the CNS. Our study suggests that this entity may have been misdiagnosed in the past as plasma cell granuloma or inflammatory pseudotumor.

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Section: Discussionmentioning

confidence: 69%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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“…The neoplasm appeared more invasive at the time of the second surgery. The dog was presented a third time 10 months later with regrowth ofa larger mass in the same location that was considered too large to remove. Further treatment was declined at that time, and the dog was lost to further follow-up.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous Plasmacytomas with Amyloid in Six Dogs

et al. 1991

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Abstract. Cutaneous plasmacytomas associated with local deposition of amyloid were diagnosed by light microscopy in a series of six older dogs (mean age 10.7 years) consisting of two Cocker Spaniels, a Poodle, a Weimeraner, and two mixed-breed dogs. The neoplasms occurred on the digits (2 dogs), forelimb (2 dogs), lip (1 dog), and ear ( I dog). In most cases, groups of neoplastic plasma cells were widely separated by large homogeneous islands of amyloid. The neoplastic cells had characteristic plasmacytoid features, but the degree of pleomorphisrn varied greatly between different neoplasms. In four of the six tumors, the diagnosis of plasmacytoma was confirmed by the demonstration ofa monoclonal plasma cell population using immunofluorescent staining for anti-canine immunoglobulins. In these tumors, the neoplastic cells reacted with only one class of immunoglobulins (IgG). The amyloid did not react with any of the reagents used. The suspicion that the amyloid was of immunoglobulin origin (primary amyloid) was supported by its retention of birefringence under polarized light after treatment with potassium permanganate and staining with Congo red.

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“…Symptoms and signs are not specific with any neurological symptoms except of intraparenchymal extension or compression of brain and cranial nerves [4]. In this case, symptomatology depends on the lesion's location [12].…”

Section: Discussionmentioning

confidence: 90%

“…Primary extramedullary plasmacytomas are uncommon, accounting for 4% of all plasma cell tumors, mainly arising in the head and neck, particularly the upper aerodigestive tract. Cranial and intracranial plasmacytomas may involve cranial vault and/or the skull base [2][3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Solitary Plasmocytoma of the Vault

Baallal¹

2014

Med chem

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Solitary plasmocytoma is rarely located in the cranial vault. We report a case of a 46-year-old Moroccan man who consulted for a medial and paramedian frontal swelling. Clinical examination revealed a large soft mass in the region frontal. Computed tomography and magnetic resonance imaging revealed an extra-axial mass. The lesion was totally excised despite the bleeding tendency. Histology disclosed the presence of a plasmacytoma. On follow up examination 3 years later no tumor recurrence or multiple myeloma was detected.

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Solitary intracranial plasmacytoma

Cited by 69 publications

References 22 publications

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Cutaneous Plasmacytomas with Amyloid in Six Dogs

Solitary Plasmocytoma of the Vault

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