Solitary Intraosseous Infantile Myofibroma of the Orbital Roof

Abstract

Background: There are several rare tumors that can cause proptosis in an infant, including infantile myofibroma. Methods: A 3-month-old infant developed a painless, bone-destructive superomedial orbital mass, raising concern for orbital malignant neoplasms. Computed tomography disclosed a bone-destructive mass of the sphenoid wing. On magnetic resonance imaging, the intraosseous mass was well-circumscribed, surrounded by cortical bone, and showed prominent enhancement. Results: Superomedial orbitotomy and biopsy revealed a lesion composed of spindled to stellate cells, without

Intraosseous Myofibroma of the Mandible: A Case Report

“…Histopathologically, a neoplasm with a biphasic pattern formed by spindle cells in fascicles and bundles, spindle nucleus with eosinophilic cytoplasm inside a hyalinized stroma was found (Poon & Kwan;Kin et al;Brasileiro et al;Nirvikalpa & Narayanan, 2011;Acosta et al). The myofibroma is positive to antibodies Actin, smooth muscle Actin and Vimentin; it is negative to Desmin S100 and EMA (Shields et al, 1998;Shibuya et al, 2008;Souza et al;Brasileiro et al;Nirvikalpa & Narayanan;Acosta et al).…”

Solitary Orbital Infantile Myofibroma: A Case Report and Review of the Literature

“…1 Review of the English language literature specific to infantile myofibromas reveals only 9 previous cases involving the orbit. [2][3][4][5][6][7][8][9] All of these lesions were solitary except for one. 5 There were 7 boys and 2 girls with an age range at presentation of birth to 6 years.…”

“…2,4,5,8 Three solitary lesions were treated with partial resection to preserve critical ocular structures and had no recurrence at follow-up of up to 7 years. 3,6,7 Solitary myofibromas in the orbit, in certain cases, can present with rapid progression and demonstrate bony erosion on imaging studies. This behavior provokes suspicion of malignant neoplasms such as rhabdomyosarcoma or neuroblastoma.…”

Orbital Infantile Myofibroma: a Case Report and Clinicopathologic Review of 24 Cases from the Literature

“…A review of the English literature based on a MEDLINE search from 1966 to 2010 was performed and all cases of infantile myofibroma involving the orbit specifically were included in the review, the majority of which were single case reports [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Clinical series of ''head and neck infantile myofibromatosis'' were selected if critical information about orbit lesions was included.…”

“…While fibromatoses [3] may occur in any region of the body, many occur in the head and neck, usually involving the superficial soft tissues. Within the head and neck, infantile myofibromatosis, although a very rare lesion, seems to show a tendency to develop around the orbit [1][2][3][4][5][6][7] in the few cases reported in the English literature [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The rarity of this tumor poses a diagnostic challenge that may lead to a misdiagnosis and subsequent inappropriate patient management.…”