Solitary Isolated Dural Metastasis From Lung Adenocarcinoma Mimicking Meningioma

Abstract

Solitary isolated dural metastasis is extremely rare. Distinguishing solitary dural metastasis from meningioma based on radiological findings can be challenging. We describe MRI and FDG PET/CT findings in 2 cases of histologically proved solitary isolated dural metastasis from lung adenocarcinoma. Enhanced brain MRI of the 2 cases showed parafalcine extra-axial, dural-based tumors with hypervascularity mimicking meningioma. Preoperative FDG PET/CT was performed in one case with a known history of lung adenocarcinoma showing intense FDG uptake of the parafalcine tumor. Postoperative FDG PET/CT was performed in the other case showing solitary lung tumor, suggestive of the primary tumor.

Solitary Dural Metastasis From Neuroblastoma Detected by 123I-MIBG SPECT/CT

“…Solitary dural metastasis only represents in approximately 4% of patients with systemic cancers, most commonly associated with breast and prostate cancers. 3,4 Solitary dural metastasis from neuroblastoma is extremely rare. In addition, the neurologic signs and symptoms are common in patients with dural metastases, including headache, vomiting, ataxia, and seizures.…”

“…Surgical pathology confirmed the diagnosis of dural metastasis from neuroblastoma. Solitary dural metastasis only represents in approximately 4% of patients with systemic cancers, most commonly associated with breast and prostate cancers 3,4 . Solitary dural metastasis from neuroblastoma is extremely rare.…”

“…The 123 I-MIBG scan in our case unsuspectedly revealed the solitary dural lesion with increased uptake. Several nuclear medicine tracers can have elevated accumulation in dural metastasis, including 18 F-FDG, 3 somatostatin analogs, 5,7 18 F-florapronol, 8 and Pittsburgh compound B 9 . Similarly, leptomeningeal metastasis can also lead to increased activity of many nuclear medicine tracers, which include 18 F-FDG, 10,11 123 I-MIBG, 12 18 F-NOTATATE, 13 18 F-FES, 14 68 Ga-DOTATATE, 15 and 68 Ga-FAPI 16 …”